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ASNDAscendis Pharma A/SSell5.8·$274.50+2.51%
SellModerate Confidence
Investment thesis

A high-growth biotech with 144% year-over-year revenue expansion, elite growth-plus-profitability metrics, and wide competitive advantages, but persistent questions about cash conversion quality and a history of large earnings misses temper the case despite a favorable 2.9-to-1 risk/reward and 20% upside to the analyst target.

Thesis pillars

  • Elite Growth And MoatStable
  • Free Cash Flow Conversion GapStable
  • Earnings Track Record VolatileStable
  • +1 more pillar — see the Why tab for full reasoning

Full reasoning →

Open full analysis

Ascendis Pharma A/S (ASND) Stock Analysis

SellVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Analyst target reached at $274.50 — A.R:R is negative (-0.3) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Near 52-week high (0.1% away).

Ascendis Pharma A/S, operates as a biopharmaceutical company that focuses on developing TransCon-based therapies for unmet medical needs in Europe, the United States, and internationally. The company offers SKYTROFA for treating pediatric patients with growth hormone deficiency;... Read more

$274.50-1.9% A.UpsideScore 5.8/10#38 of 258 Biotechnology
QualityF-score4 / 9FCF yield0.66%
Stop $255.29Target $269.39(resistance)A.R:R -0.3:1
Analyst target$293.09+6.8%18 analysts
$269.39our TP
$274.50price
$293.09mean
$249
$349

Sell if holding. Analyst target reached at $274.50 — A.R:R is negative (-0.3) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Near 52-week high (0.1% away). Chart setup: No clear chart pattern; technical signals are mixed. Score 5.8/10, moderate confidence.

Passes 7/8 gates (positive momentum, clean insider activity, no SEC red flags, news events none recent, earnings proximity no date, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio. Suitability: speculative.

TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Thu, Apr 30, 2026· next earnings call

Thesis

Rewards
Strong growth profile
Wide economic moat
Risks
Analyst target reached - limited upside remaining
Near 52-week high (0.1% away)
Leverage penalty (D/E 1.8): -1.0

Key Metrics

P/E (TTM)31.8
P/E (Fwd)25.6
Mkt Cap$18.0B
EV/EBITDA-1699.3
Profit Mgn57.3%
ROE332.7%
Rev Growth144.3%
Beta
DividendNone
Rating analysts26

Quality Signals

Piotroski F4/9MoatWideCompounder

Options Flow

P/C0.77neutral
IV55%elevated

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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About TrendMatrix. TrendMatrix is a publisher of general securities research and market commentary. We publish on a regular schedule. All content is the same for every subscriber in a tier — we do not provide personalized investment advice and we do not take into account any individual subscriber's financial situation, investment objectives, risk tolerance, tax situation, or holdings.

Not investment advice. TrendMatrix is not a registered investment adviser. Our content is for informational and educational purposes only. Consult your own licensed investment adviser, broker, or tax professional before making any investment decision.

Conflicts and positions. The TrendMatrix editorial team frequently holds personal long-term positions in securities discussed. We disclose positions held at the time of publication on each piece. We maintain a trading-window policy: we do not initiate or close positions in the same direction as a TrendMatrix publication within 24 hours before or 72 hours after publication.

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Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

2 floor-breakers

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Surprise Avg
0.0
Earnings History
1.1
Erm
5.0
Earnings concerns: 1B/2M

Technicals below the gate floor. Component breakdown shows what dragged the score down.static

Support Resistance
0.1
Bollinger
0.6
Gap
5.0
52w Position
10.0
GatesA.R:R -0.3=NEGATIVEMomentum 6.6>=5.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY NO DATESEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Speculative
RSI
93 · Overbought
20D MA 50D MA 200D MAGOLDEN CROSSSupport $203.80Resistance $274.89

Price Targets

$255
$269
A.Upside-1.9%
A.R:R-0.3:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Target reached (-3.9% upside)
! Negative risk/reward — downside exceeds upside

Earnings

B
M
M
M
1/4 beats
Next Earnings2026-04-30 (nulld)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ASND stock a buy right now?

Sell if holding. Analyst target reached at $274.50 — A.R:R is negative (-0.3) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Near 52-week high (0.1% away). Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $255.29. Score 5.8/10, moderate confidence.

What is the ASND stock price target?

Take-profit target: $269.39 (-1.9% upside). Prior stop was $255.29. Stop-loss: $255.29.

What are the risks of investing in ASND?

Analyst target reached - limited upside remaining; Near 52-week high (0.1% away); Leverage penalty (D/E 1.8): -1.0.

Is ASND overvalued or undervalued?

Ascendis Pharma A/S trades at a P/E of 31.8 (forward 25.6). TrendMatrix value score: 4.0/10. Verdict: Sell.

What do analysts say about ASND?

26 analysts cover ASND with a consensus score of 4.4/5. Average price target: $293.

What does Ascendis Pharma A/S do?Ascendis Pharma A/S, operates as a biopharmaceutical company that focuses on developing TransCon-based therapies for...

Ascendis Pharma A/S, operates as a biopharmaceutical company that focuses on developing TransCon-based therapies for unmet medical needs in Europe, the United States, and internationally. The company offers SKYTROFA for treating pediatric patients with growth hormone deficiency; and YORVIPATH, a once-daily subcutaneous injection for the treatment of adults with chronic hypoparathyroidism. It is also developing a pipeline of three independent endocrinology rare disease product candidates in clinical development, as well as focuses on advancing oncology therapeutic candidates. The company was incorporated in 2006 and is based in Hellerup, Denmark.

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