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Alnylam Pharmaceuticals, Inc. (ALNY) Stock Analysis

Temp Headwind edge

Buy WaitVALUE-TRAP 2/5Moderate Confidence

Healthcare · Biotechnology

Wait — supporting gate not met yet. Price is at or below entry $299.13 but weak momentum; below 200-day MA (death cross) still blocks BUY_NOW. Key risks: Leverage penalty (D/E 2.8): -1.5; Negative momentum.

Alnylam is a global commercial-stage biopharmaceutical company with six approved RNAi medicines, generating $2.99B in net product revenues in 2025. AMVUTTRA (vutrisiran) is the dominant revenue driver following its cardiomyopathy approval in March 2025; the company also earns... Read more

$294.71+39.1% A.UpsideScore 6.4/10#7 of 157 Biotechnology
QualityF-score8 / 9FCF yield0.52%
Entry $299.13(Support Atr Sticky)Stop $279.90Target $402.13(analyst − 10%)A.R:R 5.5:1
Analyst target$446.81+51.6%26 analysts
$402.13our TP
$294.71price
$446.81mean
$566

Wait — supporting gate not met yet. Price is at or below entry $299.13 but weak momentum; below 200-day MA (death cross) still blocks BUY_NOW. Key risks: Leverage penalty (D/E 2.8): -1.5; Negative momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Growth is cheap relative to earnings, but the chart hasn't confirmed yet (PEG 0.50, quality 8.1/10, growth 10.0/10). Score 6.4/10, moderate confidence.

Passes 7/9 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 70d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and death cross (50MA < 200MA). Suitability: moderate.

Recent Developments — Alnylam Pharmaceuticals, Inc.

Generated 2026-05-20T20:21:21Z.

Thesis

Rewards
V7 flight-to-quality bonus: +0.5 (Q=8.1 in RISK_OFF)
Sector modifier (Healthcare): +0.5
Strong earnings beat streak (3/4)
Risks
Leverage penalty (D/E 2.8): -1.5
Negative momentum
Below 200-day MA

Key Metrics

P/E (TTM)74.1
P/E (Fwd)20.8
Mkt Cap$39.3B
EV/EBITDA48.6
Profit Mgn12.6%
ROE90.4%
Rev Growth96.4%
Beta0.30
DividendNone
Rating analysts36

Quality Signals

Piotroski F8/9MoatWideCompounder

Options Flow

P/C0.42bullish
IV42%normal
Max Pain$700+137.5% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

1 floor-breaker·1 ceiling hit

Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static

Volume
0.0
Obv
1.0
Ma Position
1.5
Rsi
3.5
Macd
10.0
Volume distribution (falling OBV)Below 200-MA, MA slope flat
GatesMomentum 3.2<4.5Death cross (50MA < 200MA)A.R:R 5.5 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 70d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Moderate
RSI
40 · Neutral
20D MA 50D MA 200D MADEATH CROSSSupport $284.28Resistance $317.56

Price Targets

$280
$299
$402
A.Upside+36.4%
A.R:R5.5:1

Position Sizing

ConvictionHigh conviction
Suggested %1.7%
Max %3.4%
RegimeRisk-Off

Risk Alerts

! News modifier capped: WAIT cannot upgrade to NOW via sentiment alone
! Momentum score 3.2/10 — below 4.5 minimum
! Death cross — 50-day MA below 200-day MA

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-07-30 (70d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ALNY stock a buy right now?

Wait — supporting gate not met yet. Price is at or below entry $299.13 but weak momentum; below 200-day MA (death cross) still blocks BUY_NOW. Key risks: Leverage penalty (D/E 2.8): -1.5; Negative momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Growth is cheap relative to earnings, but the chart hasn't confirmed yet (PEG 0.50, quality 8.1/10, growth 10.0/10). Target $402.13 (+36.4%), stop $279.90 (−5.3%), Setup A.R:R 8.5:1. Score 6.4/10, moderate confidence.

What is the ALNY stock price target?

Take-profit target: $402.13 (+39.1% upside). Target $402.13 (+36.4%), stop $279.90 (−5.3%), Setup A.R:R 8.5:1. Stop-loss: $279.90.

What are the risks of investing in ALNY?

Leverage penalty (D/E 2.8): -1.5; Negative momentum; Below 200-day MA.

Is ALNY overvalued or undervalued?

Alnylam Pharmaceuticals, Inc. trades at a P/E of 74.1 (forward 20.8). TrendMatrix value score: 5.7/10. Verdict: Buy (Wait for Entry).

What do analysts say about ALNY?

36 analysts cover ALNY with a consensus score of 3.9/5. Average price target: $447.

What does Alnylam Pharmaceuticals, Inc. do?Alnylam is a global commercial-stage biopharmaceutical company with six approved RNAi medicines, generating $2.99B in...

Alnylam is a global commercial-stage biopharmaceutical company with six approved RNAi medicines, generating $2.99B in net product revenues in 2025. AMVUTTRA (vutrisiran) is the dominant revenue driver following its cardiomyopathy approval in March 2025; the company also earns collaboration royalties from Novartis (Leqvio) and Sanofi (Qfitlia).

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