Lantheus Holdings operates a high-quality specialty healthcare franchise with exceptional free cash flow conversion and a perfect financial health score, but the stock has moved above its near-term price target, leaving the risk/reward firmly negative at the current price.
Thesis pillars
- Exceptional Cash Generation Quality→Stable
- Attractive Growth Adjusted Valuation→Stable
- Consecutive Earnings Outperformance↓Deteriorating
- +1 more pillar — see the Why tab for full reasoning
Lantheus Holdings, Inc. (LNTH) Stock Analysis
Healthcare · Drug Manufacturers - Specialty & Generic
Hold if already holding. Not a fresh buy at $100.97, but acceptable to hold if already in. Reasons: Concentration risk — Supplier: sole suppliers (synthesis boxes, lipid blend); Analyst target reached - limited upside remaining.
Lantheus Holdings markets PYLARIFY (prostate cancer PSMA PET imaging, FDA-approved May 2021), DEFINITY (ultrasound contrast agent with estimated over 80% U.S. echocardiography segment share), and Neuraceq (Alzheimer's amyloid PET) to hospitals and imaging centers primarily in... Read more
Hold if already holding. Not a fresh buy at $100.97, but acceptable to hold if already in. Reasons: Concentration risk — Supplier: sole suppliers (synthesis boxes, lipid blend); Analyst target reached - limited upside remaining. Chart setup: No clear chart pattern; technical signals are mixed. Maintain position. Not compelling to add more. Score 6.2/10, moderate confidence.
Passes 6/9 gates (positive momentum, clean insider activity, news events none recent, earnings proximity 61d clear, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio. Suitability: moderate.
About Lantheus Holdings, Inc.
About Lantheus Holdings, Inc.
Lantheus Holdings markets PYLARIFY (piflufolastat F-18, FDA-approved May 2021) for prostate PSMA PET imaging, DEFINITY ultrasound contrast with an estimated over 80% share of the U.S. echocardiography ultrasound enhancing agent segment, and Neuraceq for Alzheimer's amyloid PET imaging — acquired via Life Molecular Imaging in July 2025 for $352.9 million. On January 1, 2026, the company sold its SPECT business to SHINE Technologies for up to $155.0 million, sharpening focus on PET radiodiagnostics and microbubbles.
Lantheus earns revenue across three categories: Radiopharmaceutical Oncology (dominated by PYLARIFY), Precision Diagnostics (DEFINITY, Neuraceq), and Strategic Partnerships, which includes royalties, milestones, and CDMO revenue from Evergreen Theragnostics (acquired April 1, 2025 for $276.4 million upfront). PYLARIFY is sold to hospitals, independent imaging centers, and government facilities in the United States through an internal sales team and selected PMF partner sales teams; reimbursement shifted from ASP-plus-six-percent under expired TPT Status (through December 31, 2024) to a mean unit cost basis under the CMS 2026 OPPS Rule — paying at a lower rate than competing PSMA agents from Telix Pharmaceuticals, Novartis, and Blue Earth Diagnostics that retain TPT Status. DEFINITY relies on Jubilant HollisterStier as a substantial supplier and competes with GE Healthcare and Bracco Diagnostics. The company also purchases certain key raw materials from sole suppliers, including the specially designed synthesis boxes for PYLARIFY manufacturing and lipid blend material and perflutren gas for DEFINITY.
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PYLARIFY's five-year new chemical entity exclusivity expires May 26, 2026, potentially opening the ANDA pathway to generic challengers under the Hatch-Waxman Act. Lantheus holds six Orange Book-listed patents for PYLARIFY, the last expiring in 2037; a timely Paragraph IV lawsuit could trigger a 30-month FDA stay potentially extending to November 2028. Separately, Lantheus submitted an NDA for a new PYLARIFY formulation with an FDA PDUFA target date of March 6, 2026 — if approved, the company plans to seek three years of renewed TPT Status from CMS, which could partially offset the reimbursement disadvantage versus agents retaining existing TPT Status.
See also: Healthcare · Drug Manufacturers - Specialty & Generic
From Lantheus Holdings, Inc.'s most recent 10-K filing, extracted June 11, 2026.
Recent developments
updated 2026-09-04Recent Developments — Lantheus Holdings, Inc.
Latest news
- NEWS LNTH Maintained by Mizuho -- Price Target Lowered to $115 - GuruFocus — GuruFocus neutral
- NEWS Analysts Are Bullish on Top Healthcare Stocks: IQVIA Holdings (IQV), Lantheus (LNTH) - The Globe and Mail — The Globe and Mail neutral
- NEWS Mizuho raises Lantheus stock price target to $115 amid sale talks By Investing.com - Investing.com South Africa — Investing.com South Africa positive
- NEWS Mizuho raises Lantheus stock price target to $115 amid sale talks - Investing.com — Investing.com positive
- NEWS Mizuho raises Lantheus stock price target to $115 amid sale talks - Investing.com Nigeria — Investing.com Nigeria positive
Generated 2026-09-04T19:02:09Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- MEDIUMProductPYLARIFY10-K Item 1A: 'Continued substantial revenue contribution from PYLARIFY is dependent on'
- MEDIUMSupplierJubilant HollisterStier10-K Item 1A: 'We rely on Jubilant HollisterStier as a substantial supplier of DEFINITY'
- HIGHSuppliersole suppliers (synthesis boxes, lipid blend)10-K Item 1A: 'we purchase certain components and raw materials from sole suppliers (including, for example, the specially designed chemistry synthesis boxes'
Material Events(8-K, last 90d)
- 2026-05-01Item 3.03LOWCharter amendment on April 30, 2026 modified rights of security holders per Item 5.03 (content truncated); related to shareholder approval of the A&R 2026 Equity Incentive Plan, which added 2,000,000 shares and changed non-employee director compensation limits.SEC filing →
- 2026-05-01Item 5.02LOWShareholders approved A&R 2026 Equity Incentive Plan on April 30, 2026: added 2,000,000 shares, changed non-employee director comp limits to $1,250,000 (appointment year) and $750,000 (subsequent years), removed certain Section 162(m) provisions.SEC filing →
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
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Price Targets
Position Sizing
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Earnings
Verdict History
Frequently Asked Questions
Hold if already holding. Not a fresh buy at $100.97, but acceptable to hold if already in. Reasons: Concentration risk — Supplier: sole suppliers (synthesis boxes, lipid blend); Analyst target reached - limited upside remaining. Chart setup: No clear chart pattern; technical signals are mixed. Maintain position. Not compelling to add more. Target $116.11 (+15.0%), stop $99.89 (−1.1%), A.R:R -0.5:1. Score 6.2/10, moderate confidence.
Take-profit target: $116.11 (-7.7% upside). Target $116.11 (+15.0%), stop $99.89 (−1.1%), A.R:R -0.5:1. Stop-loss: $99.89.
Concentration risk — Supplier: sole suppliers (synthesis boxes, lipid blend); Analyst target reached - limited upside remaining; Earnings estimates trending DOWN.
Lantheus Holdings, Inc. trades at a P/E of 24.1 (forward 16.0). TrendMatrix value score: 6.3/10. Verdict: Hold.
17 analysts cover LNTH with a consensus score of 3.6/5. Average price target: $107.
What does Lantheus Holdings, Inc. do?Lantheus Holdings markets PYLARIFY (prostate cancer PSMA PET imaging, FDA-approved May 2021), DEFINITY (ultrasound...
Lantheus Holdings markets PYLARIFY (prostate cancer PSMA PET imaging, FDA-approved May 2021), DEFINITY (ultrasound contrast agent with estimated over 80% U.S. echocardiography segment share), and Neuraceq (Alzheimer's amyloid PET) to hospitals and imaging centers primarily in the United States. Revenue comes from product sales, royalties, milestone payments, and CDMO services.