BioCryst combines 34% revenue growth, positive free cash flow and a perfect 4-quarter beat streak with a forward P/E of 10.3x and large analyst upside, though earnings are due in 3 days and the stock is below its long-term trend.
Thesis pillars
- Fcf Positive High Quality→Stable
- Margin Compression Insider Selling↑Improving
- Strong Revenue Growth→Stable
- +2 more pillars — see the Why tab for full reasoning
Pillars as of Nov 1, 2026, based on the 10-K filed Feb 26, 2026
BioCryst Pharmaceuticals, Inc. (BCRX) Stock Analysis
Range Bound setup
Healthcare · Drug Manufacturers - Specialty & Generic
Wait for pullback to $7.87. BUY gates pass at $8.24, but the engine prefers a shallower entry for a wider margin of safety. Engine's entry $7.87 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum.
BioCryst Pharmaceuticals commercializes ORLADEYO (berotralstat), an oral once-daily prophylactic therapy for hereditary angioedema (HAE) with FDA approval since December 2020, alongside peramivir injection (RAPIVAB) for influenza. Revenue comes from direct U.S. ORLADEYO sales... Read more
Wait for pullback to $7.87. BUY gates pass at $8.24, but the engine prefers a shallower entry for a wider margin of safety. Engine's entry $7.87 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Chart setup: RSI 54 mid-range, Bollinger mid-band. Exceptional business at discount. Quality + value alignment. Score 7.4/10, high confidence.
Passes 8/8 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost earnings 0.70, earnings proximity no date, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.
About BioCryst Pharmaceuticals, Inc.
About BioCryst Pharmaceuticals, Inc.
ORLADEYO (berotralstat), BioCryst's oral once-daily prophylactic HAE therapy, received FDA approval in December 2020 for patients 12 years and older, followed by a second FDA approval in December 2025 for a pediatric pellet formulation for patients aged 2 to under 12. BioCryst targets a global peak of $1 billion in annual ORLADEYO net revenues, based on five full years of U.S. commercialization and an HAE prevalence of 1 in 33,000 to 1 in 67,000 people. In October 2025, the company completed the sale of its European ORLADEYO operations to Neopharmed Gentili for $250 million, while retaining exclusive supply obligations for the European territory.
BioCryst generates revenue from direct ORLADEYO sales in the U.S. through a specialty pharmacy operating the EMPOWER Patient Services program. Japan commercialization is handled by Torii Pharmaceutical under a tiered royalty agreement ranging from 20% on annual sales below a prespecified threshold to 80% above it; pan-Latin America is covered by Pint Pharma under an exclusive collaboration. Peramivir injection (RAPIVAB) had a $69 million HHS contract for up to 95,625 doses over five years, but in May 2025 the U.S. ASPR notified the company of its intent not to exercise any additional optional ordering periods under the agreement. The company funded ORLADEYO development in part through royalty purchase agreements with RPI 2019 Intermediate Finance Trust and OMERS Capital Markets, creating ongoing royalty payment obligations distinct from traditional debt. Following the January 23, 2026 merger with Astria Therapeutics, navenibart—a monoclonal antibody plasma kallikrein inhibitor targeting every 3- and 6-month dosing for HAE—became the company's primary Phase 3 pipeline asset.
Show full overview
Navenibart constitutes the critical pipeline binary event: it is currently in Phase 3 clinical development with FDA Fast Track and Orphan Drug designations, and if trial results are negative or delayed the near-term pipeline would consist only of early-stage assets—Phase 1 BCX17725 for Netherton syndrome (up to 12-patient data expected by end of 2026) and Phase 1 Avoralstat for diabetic macular edema. STAR-0310, an OX40 antagonist acquired in the Astria merger, is in Phase 1a with the company planning to seek strategic alternatives for the asset, further concentrating the actionable pipeline around navenibart.
See also: Healthcare · Drug Manufacturers - Specialty & Generic
From BioCryst Pharmaceuticals, Inc.'s most recent 10-K filing, extracted June 9, 2026.
Recent developments
updated Nov 4, 2026Recent Developments — BioCryst Pharmaceuticals, Inc.
Latest news
- NEWS Earnings Flash (BCRX) BioCryst Pharmaceuticals, Inc. Reports Q3 Revenue $180.3M, vs. FactSet Est of $165.7M - www.market — www.marketscreener.com Nov 4, 2026 positive
- NEWS BioCryst Pharmaceuticals (BCRX) Surpasses Q3 Earnings and Revenue Estimates - Yahoo Finance — Yahoo Finance Nov 4, 2026 positive
- NEWS BioCryst Pharmaceuticals (BCRX) Earnings Expected to Grow: What to Know Ahead of Next Week's Release - Yahoo Finance — Yahoo Finance Oct 28, 2026 positive
- NEWS BioCryst Pharmaceuticals (BCRX) Wins FDA Nod As ORLADEYO Bulls Ask If The Stock Is A Bargain - Simply Wall St — Simply Wall St Oct 28, 2026 positive
- NEWS BioCryst Pharmaceuticals (BCRX) Wins FDA Nod As ORLADEYO Bulls Ask If The Stock Is A Bargain - Simply Wall Street — Simply Wall Street Oct 28, 2026 positive
Latest item Nov 4, 2026 · Generated 2026-11-05T11:29:00Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- MEDIUMProductORLADEYO10-K Item 1: 'We have built a robust commercial infrastructure to support the successful commercialization of ORLADEYO'
- MEDIUMpipelinenavenibart10-K Item 1: 'Navenibart is currently in Phase 3 clinical development, and the FDA has granted Fast Track and Orphan Drug designations to navenibart'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. How we score · Editorial policy
Show full disclosure ▾Hide full disclosure ▴
About TrendMatrix. TrendMatrix is a publisher of general securities research and market commentary. We publish on a regular schedule. All content is the same for every subscriber in a tier — we do not provide personalized investment advice and we do not take into account any individual subscriber's financial situation, investment objectives, risk tolerance, tax situation, or holdings.
Not investment advice. TrendMatrix is not a registered investment adviser. Our content is for informational and educational purposes only. Consult your own licensed investment adviser, broker, or tax professional before making any investment decision.
Conflicts and positions. People who build TrendMatrix, or entities they control, may hold positions, long or short, in securities it covers, and may trade them at any time. Positions are not disclosed individually. Verdicts are generated by an automated model applied by the same rules to every covered stock, and are not adjusted for any position held by the people who build TrendMatrix. We do not accept payment from issuers for coverage.
No paid promotion. TrendMatrix does not accept payment from any issuer, broker, or third party in exchange for coverage of any security.
No fiduciary duty. No fiduciary, advisory, or agency relationship is created between you and TrendMatrix by reading our content or subscribing to our service.
Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.
Rating Breakdown
2 ceiling hits
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Wait for pullback to $7.87. BUY gates pass at $8.24, but the engine prefers a shallower entry for a wider margin of safety. Engine's entry $7.87 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Chart setup: RSI 54 mid-range, Bollinger mid-band. Exceptional business at discount. Quality + value alignment. Target $17.87 (+116.9%), stop $7.32 (−12.6%), A.R:R 13.4:1. Score 7.4/10, high confidence.
Take-profit target: $17.87 (+116.9% upside). Target $17.87 (+116.9%), stop $7.32 (−12.6%), A.R:R 13.4:1. Stop-loss: $7.32.
BioCryst Pharmaceuticals, Inc. trades at a P/E of N/A (forward 10.0). TrendMatrix value score: 9.0/10. Verdict: Buy (Wait for Entry).
17 analysts rate BCRX, with a consensus score of 4.1/5. 11 analysts publish price targets averaging $21.
What does BioCryst Pharmaceuticals, Inc. do?BioCryst Pharmaceuticals commercializes ORLADEYO (berotralstat), an oral once-daily prophylactic therapy for hereditary...
BioCryst Pharmaceuticals commercializes ORLADEYO (berotralstat), an oral once-daily prophylactic therapy for hereditary angioedema (HAE) with FDA approval since December 2020, alongside peramivir injection (RAPIVAB) for influenza. Revenue comes from direct U.S. ORLADEYO sales and royalties from partners including Torii (Japan); the company sold its European ORLADEYO business to Neopharmed Gentili for $250 million in October 2025 and acquired Phase 3 navenibart via the Astria merger in January 2026.