Agios carries deep quality deficiencies — free cash flow at -405% of revenue, no competitive moat, and quality well below the minimum investment threshold — while technically strong momentum and three consecutive earnings beats reflect near-term execution; the risk/reward geometry of 0.67 to 1 and short interest at 12% make this a setup to avoid absent a catalyst that substantially improves the fundamental picture.
Thesis pillars
- Elevated Institutional Skepticism→Stable
- Deep Quality Deficiency Cash Burn→Stable
- Strong Near Term Momentum↓Deteriorating
- +1 more pillar — see the Why tab for full reasoning
Agios Pharmaceuticals, Inc. (AGIO) Stock Analysis
Healthcare · Biotechnology
Sell if holding. Engine safety override at $37.36: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10. Specifically: High short interest: 11%; Below-average business quality; Rich valuation.
Agios Pharmaceuticals is a commercial-stage rare hematology company with two approved medicines: PYRUKYND® (mitapivat) for PK deficiency in the U.S. and EU, and AQVESME™ (mitapivat) FDA-approved in December 2025 for thalassemia. PYRUKYND® generated $54.0 million in net product... Read more
Sell if holding. Engine safety override at $37.36: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10. Specifically: High short interest: 11%; Below-average business quality; Rich valuation. Chart setup: No clear chart pattern; technical signals are mixed. Score 5.3/10, moderate confidence.
Passes 5/8 gates (clean insider activity, no SEC red flags, news events none recent, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and favorable risk/reward ratio and earnings proximity 4d<=7d. Suitability: speculative.
About Agios Pharmaceuticals, Inc.
About Agios Pharmaceuticals, Inc.
Agios Pharmaceuticals' two approved medicines—PYRUKYND for PK deficiency (approved in the U.S., EU, and Great Britain) and AQVESME for thalassemia (FDA-approved December 2025)—both contain mitapivat, an oral pyruvate kinase activator. PYRUKYND generated $54.0 million in net product revenues in the year ended December 31, 2025, compared with $36.5 million in 2024 and $26.8 million in 2023. AQVESME launched commercially in late January 2026 following FDA approval and implementation of a Risk Evaluation and Mitigation Strategy to monitor hepatocellular injury risk.
Agios earns product revenue from direct U.S. sales of PYRUKYND and AQVESME, and rest-of-world royalties under two distribution agreements: the Avanzanite Agreement (European Economic Area, Switzerland, and the United Kingdom, signed June 2025) and the NewBridge Agreement (Gulf Council Countries, signed July 2024). The company retains full ownership of both approved medicines and funds their development and commercialization costs. The commercial patient population is narrow—PK deficiency affects an estimated 3,000–8,000 individuals in the U.S. and EU5, while thalassemia prevalence in those same markets is roughly 18,000–23,000. Beyond product revenue, Agios retains a 3% earn-out on vorasidenib U.S. net sales above $1.0 billion per year following the August 2024 sale of the Vorasidenib Royalty Rights to Royalty Pharma for $905.0 million. The remaining pipeline includes tebapivat for lower-risk MDS and SCD, AG-181 for phenylketonuria, and AG-236 licensed from Alnylam Pharmaceuticals targeting TMPRSS6 for polycythemia vera.
Show full overview
The next significant binary event is FDA review of the sickle cell disease application for mitapivat: the Phase 3 RISE UP trial achieved the hemoglobin response primary endpoint (40.6% response vs. 2.9% placebo, p<0.0001) but missed the co-primary annualized pain crises endpoint (p=0.1213). Agios plans a pre-supplemental NDA meeting with the FDA in the first quarter of 2026 before submitting the U.S. marketing application; regulatory acceptance of a mixed-endpoint package could expand the mitapivat franchise into a U.S. and EU5 patient population of approximately 120,000–135,000—substantially larger than either current approved indication.
See also: Healthcare · Biotechnology
From Agios Pharmaceuticals, Inc.'s most recent 10-K filing, extracted June 9, 2026.
Recent developments
updated 2026-07-26Recent Developments — Agios Pharmaceuticals, Inc.
Latest news
- NEWS 10 Health Care Stocks With Whale Alerts In Today’s Session — benzinga Jul 21, 2026 neutral
- NEWS Agios Reports Neutral Sickle Cell Data, Decides To Stop Development — benzinga Jul 21, 2026 negative
- NEWS HC Wainwright & Co. Maintains Buy on Agios Pharmaceuticals, Lowers Price Target to $52 — benzinga Jul 21, 2026 neutral
- NEWS Danaher Posts Q2 Results, Joins Calix, Equifax And Other Big Stocks Moving Lower In Tuesday’s Pre-Market Session — benzinga Jul 21, 2026 negative
- NEWS Agios Pharma Announces Topline Results From Phase 2 Trial Of Tebapivat, Oral Pyruvate Kinase Activator, In Patients Aged — benzinga Jul 21, 2026 positive
Generated 2026-07-26T09:22:59Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHProductPYRUKYND® / AQVESME™10-K Item 1A: 'Our ability to generate meaningful revenue from PYRUKYND® and AQVESME™ will depend heavily on our successful development and commercialization of the product'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
3 floor-breakers·1 ceiling hit
Quality below the gate floor. Component breakdown shows what dragged the score down.static
Momentum below the gate floor. Component breakdown shows what dragged the score down.static
Priced at a premium — multiples above sector norms. Needs delivery on growth + margins to justify.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $37.36: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10. Specifically: High short interest: 11%; Below-average business quality; Rich valuation. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $34.04. Score 5.3/10, moderate confidence.
Take-profit target: $36.87 (+1.4% upside). Prior stop was $34.04. Stop-loss: $34.04.
Concentration risk — Product: PYRUKYND® / AQVESME™; Target reached (1.4% upside); Quality below floor (1.9 < 4.0).
Agios Pharmaceuticals, Inc. trades at a P/E of N/A (forward -8.0). TrendMatrix value score: 3.0/10. Verdict: Sell.
16 analysts cover AGIO with a consensus score of 4.1/5. Average price target: $42.
What does Agios Pharmaceuticals, Inc. do?Agios Pharmaceuticals is a commercial-stage rare hematology company with two approved medicines: PYRUKYND® (mitapivat)...
Agios Pharmaceuticals is a commercial-stage rare hematology company with two approved medicines: PYRUKYND® (mitapivat) for PK deficiency in the U.S. and EU, and AQVESME™ (mitapivat) FDA-approved in December 2025 for thalassemia. PYRUKYND® generated $54.0 million in net product revenues in 2025 and AQVESME™ launched commercially in the United States in late January 2026.