Enliven Therapeutics, Inc. (ELVN) Stock Analysis
Breakout setup
Healthcare · Biotechnology
Sell if holding. Engine safety override at $42.55: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 1.5:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Below-average business quality.
Enliven Therapeutics is a clinical-stage biopharmaceutical company developing ELVN-001, a highly selective BCR-ABL tyrosine kinase inhibitor in Phase 1 ENABLE trial for chronic myeloid leukemia (CML), with Phase 3 ENABLE-2 planned for 2H 2026. The company has no approved... Read more
Sell if holding. Engine safety override at $42.55: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 1.5:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 52, MACD bullish. Score 5.6/10, moderate confidence.
Passes 8/8 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 57d clear, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.
About Enliven Therapeutics, Inc.
About Enliven Therapeutics, Inc.
ELVN-001, Enliven Therapeutics' BCR-ABL tyrosine kinase inhibitor targeting chronic myeloid leukemia, had 90 patients enrolled in the Phase 1 ENABLE trial as of the April 28, 2025 data cutoff, with a reported cumulative major molecular response rate of 47% at 24 weeks across dose levels ranging from 10 mg once daily to 80 mg twice daily. The company reported a net loss of $103.7 million for the year ended December 31, 2025 and carries $347.2 million in accumulated deficit with no product revenue generated to date.
Enliven Therapeutics is a clinical-stage company financing operations entirely through equity issuances. ELVN-001 targets the BCR-ABL fusion gene — the oncogenic driver present in approximately 95% of CML patients diagnosed in chronic phase — as an ATP-competitive inhibitor designed to avoid the off-target kinase activity that causes cardiovascular and metabolic side effects in second-generation TKIs such as dasatinib and nilotinib. The company competes in a market currently anchored by Novartis' Scemblix (asciminib), which achieved a $1.6 billion annualized sales run-rate in the fourth quarter of 2025 with projected peak annual sales of $4 billion. GMP APIs for ELVN-001 are manufactured solely by Pharmaron; drug product is produced at Latitude Pharmaceuticals, Quotient Sciences, and CoreRx under contract manufacturing arrangements. The company is exploring strategic alternatives for ELVN-002, a HER2 inhibitor deprioritized in May 2025, concentrating all resources on ELVN-001 and the planned Phase 3 ENABLE-2 trial targeting second-line-plus CML patients.
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The company's NPV is essentially a binary bet on ELVN-001 advancing through Phase 3. In January 2026, updated Phase 1b data from the 80 mg once-daily cohort (n=19) showed an MMR rate of 38% and deep molecular response rate of 16%, while the randomized 60 mg and 120 mg cohort (n=41) showed 53% MMR and 35% DMR at 24 weeks, comparing favorably to asciminib's pivotal trial precedent. FDA alignment on dose selection for ENABLE-2 is pending; any major protocol objection or Complete Response Letter could delay Phase 3 initiation beyond the planned second-half 2026 target, leaving the company to fund operations from existing capital while no revenue-generating path exists.
See also: Healthcare · Biotechnology
From Enliven Therapeutics, Inc.'s most recent 10-K filing, extracted June 10, 2026.
Recent developments
updated 2026-06-17Recent Developments — Enliven Therapeutics, Inc.
Latest news
- NEWS Reported Earlier, Enliven Therapeutics Prices Upsized Public Offering Of 8,933,334 Common Shares At $37.50, Pre-Funded W — benzinga Jun 12, 2026 positive
- NEWS Crude Oil Edges Higher; Driven Brands Posts Upbeat Earnings — benzinga Jun 11, 2026 neutral
- NEWS Stitch Fix, Intel, KLA And Other Big Stocks Moving Higher On Thursday — benzinga Jun 11, 2026 positive
- NEWS Enliven Therapeutics Presents Data From The Phase 1 Enable Clinical Trial Evaluating ELVN-001 In Patients With Previousl — benzinga Jun 11, 2026 positive
- NEWS This Grand Canyon Education Analyst Begins Coverage On A Bullish Note; Here Are Top 4 Initiations For Tuesday — benzinga Jun 9, 2026 neutral
Generated 2026-06-17T08:41:50Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHpipelineELVN-00110-K Item 1A: 'We are substantially dependent on ELVN-001. If we are unable to advance ELVN-001 through clinical development, obtain regulatory approval and ultimately commercialize or license ELVN-001...our business will be materially harmed.'
- HIGHSupplierPharmaron10-K Item 1: 'we have obtained the custom-manufactured starting materials for active pharmaceutical ingredients ("APIs") manufacture from Pharmaron and Hande Sciences and our good manufacturing practice ("GMP") APIs from Pharmaron.'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
1 floor-breaker
Quality below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $42.55: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 1.5:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 52, MACD bullish. Prior stop was $39.57. Score 5.6/10, moderate confidence.
Take-profit target: $52.30 (+22.9% upside). Prior stop was $39.57. Stop-loss: $39.57.
Concentration risk — Pipeline: ELVN-001; Concentration risk — Supplier: Pharmaron; Quality below floor (1.6 < 4.0).
Enliven Therapeutics, Inc. trades at a P/E of N/A (forward -17.4). TrendMatrix value score: 7.5/10. Verdict: Sell.
17 analysts cover ELVN with a consensus score of 4.3/5. Average price target: $60.
What does Enliven Therapeutics, Inc. do?Enliven Therapeutics is a clinical-stage biopharmaceutical company developing ELVN-001, a highly selective BCR-ABL...
Enliven Therapeutics is a clinical-stage biopharmaceutical company developing ELVN-001, a highly selective BCR-ABL tyrosine kinase inhibitor in Phase 1 ENABLE trial for chronic myeloid leukemia (CML), with Phase 3 ENABLE-2 planned for 2H 2026. The company has no approved products or revenue and is substantially dependent on ELVN-001 for all future commercial value.