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Krystal Biotech, Inc. (KRYS) Stock Analysis

Temp Headwind edge

Buy WaitVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Wait for pullback to $271.04. Weak momentum — blocks BUY_NOW at $298.47. Engine's entry $271.04 (50-day MA) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Analyst target reached - limited upside remaining; Expensive valuation.

Krystal Biotech is a commercial-stage biotech that develops, manufactures, and commercializes HSV-1-based gene therapies; its lead product VYJUVEK is approved in the US, EU, and Japan for dystrophic epidermolysis bullosa (DEB), with $730.3M in cumulative net product revenue... Read more

$298.47+15.5% A.UpsideScore 6.1/10#18 of 157 Biotechnology
QualityF-score9 / 9FCF yield1.59%
Entry $271.04(50-day MA)Stop $252.07Target $313.09(resistance)A.R:R -0.5:1Setup A.R:R 2.2:1
Analyst target$322.78+8.1%9 analysts
$313.09our TP
$298.47price
$322.78mean
$241
$399

Wait for pullback to $271.04. Weak momentum — blocks BUY_NOW at $298.47. Engine's entry $271.04 (50-day MA) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Analyst target reached - limited upside remaining; Expensive valuation. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Growth is cheap relative to earnings, but the chart hasn't confirmed yet (PEG 0.55, quality 7.9/10, growth 10.0/10). Score 6.1/10, moderate confidence.

Passes 6/8 gates (clean insider activity, no SEC red flags, news boost analyst 0.70, earnings proximity 75d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and favorable risk/reward ratio. Suitability: moderate.

Recent Developments — Krystal Biotech, Inc.

Generated 2026-05-20T21:06:21Z.

Thesis

Rewards
V7 quality resilience bonus: +0.2 (Q=7.9 in RISK_OFF)
Sector modifier (Healthcare): +0.5
Strong earnings beat streak (3/4)
Risks
Analyst target reached - limited upside remaining
Expensive valuation
Negative momentum

Key Metrics

P/E (TTM)39.3
P/E (Fwd)29.1
Mkt Cap$8.6B
EV/EBITDA43.4
Profit Mgn53.9%
ROE19.9%
Rev Growth31.9%
Beta0.49
DividendNone
Rating analysts18

Quality Signals

Piotroski F9/9MoatWideCompounder

Options Flow

P/C0.43bullish
IV42%normal
Max Pain$185-38.0% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

1 floor-breaker·1 ceiling hit

Momentum below the gate floor. Component breakdown shows what dragged the score down.static

Volume
0.0
Macd
0.4
Obv
1.0
Rsi
4.5
Ma Position
9.0
Overbought (RSI 71)Volume distribution (falling OBV)Above 200-day MA
GatesMomentum 3.0<4.5A.R:R -0.5=NEGATIVEInsider activity: OKNo SEC red flagsNEWS BOOST ANALYST 0.70EARNINGS PROXIMITY 75d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Moderate
RSI
71 · Overbought
20D MA 50D MA 200D MAGOLDEN CROSSSupport $251.97Resistance $319.48

Price Targets

$252
$271
$313
A.Upside+4.9%
A.R:R-0.5:1
Setup A.R:R (at entry)2.2:1

Position Sizing

ConvictionHigh conviction
Suggested %0.6%
Max %1.1%
RegimeRisk-Off

Risk Alerts

! Target reached (-7.4% upside)
! Momentum score 3.0/10 — below 4.5 minimum
! Negative risk/reward — downside exceeds upside

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-08-03 (75d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is KRYS stock a buy right now?

Wait for pullback to $271.04. Weak momentum — blocks BUY_NOW at $298.47. Engine's entry $271.04 (50-day MA) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Analyst target reached - limited upside remaining; Expensive valuation. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Growth is cheap relative to earnings, but the chart hasn't confirmed yet (PEG 0.55, quality 7.9/10, growth 10.0/10). Target $313.09 (+4.9%), stop $252.07 (−18.4%), Setup A.R:R 2.2:1. Score 6.1/10, moderate confidence.

What is the KRYS stock price target?

Take-profit target: $313.09 (+15.5% upside). Target $313.09 (+4.9%), stop $252.07 (−18.4%), Setup A.R:R 2.2:1. Stop-loss: $252.07.

What are the risks of investing in KRYS?

Analyst target reached - limited upside remaining; Expensive valuation; Negative momentum.

Is KRYS overvalued or undervalued?

Krystal Biotech, Inc. trades at a P/E of 39.3 (forward 29.1). TrendMatrix value score: 4.0/10. Verdict: Buy (Wait for Entry).

What do analysts say about KRYS?

18 analysts cover KRYS with a consensus score of 4.3/5. Average price target: $323.

What does Krystal Biotech, Inc. do?Krystal Biotech is a commercial-stage biotech that develops, manufactures, and commercializes HSV-1-based gene...

Krystal Biotech is a commercial-stage biotech that develops, manufactures, and commercializes HSV-1-based gene therapies; its lead product VYJUVEK is approved in the US, EU, and Japan for dystrophic epidermolysis bullosa (DEB), with $730.3M in cumulative net product revenue since 2023 launch. Pipeline includes KB407 (CF, Phase 1) and KB408 (AATD, Phase 1), supported by two in-house CGMP manufacturing facilities.

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