United Therapeutics generates 41% net margins and ranks best-in-class on margins among specialty pharmaceutical peers, but severe product concentration where Tyvaso DPI and Nebulized Tyvaso together account for 59% of revenue, combined with 3 earnings misses in 4 quarters, makes the current risk profile unfavorable for new positions.
Thesis pillars
- Best In Class Pharma Margins→Stable
- Product Concentration Tyvaso↑Improving
- Earnings Miss Trajectory→Stable
- +1 more pillar — see the Why tab for full reasoning
United Therapeutics Corporation (UTHR) Stock Analysis
Healthcare · Drug Manufacturers - Specialty & Generic
Sell if holding. Momentum 1.9/10 is below the 5.0 floor at $499.73 — engine's falling-knife protection flags exit rather than catching a breakdown. Specifics: Concentration risk — Product: Tyvaso DPI and Nebulized Tyvaso (59.0%); Concentration risk — Customer: Accredo and CVS Specialty.
United Therapeutics markets five therapies for pulmonary arterial hypertension and rare diseases — Tyvaso DPI, Nebulized Tyvaso, Remodulin, Orenitram, and Unituxin — generating approximately $3.16 billion in total revenues in 2025. Tyvaso DPI and Nebulized Tyvaso together... Read more
Sell if holding. Momentum 1.9/10 is below the 5.0 floor at $499.73 — engine's falling-knife protection flags exit rather than catching a breakdown. Specifics: Concentration risk — Product: Tyvaso DPI and Nebulized Tyvaso (59.0%); Concentration risk — Customer: Accredo and CVS Specialty. Chart setup: No clear chart pattern; technical signals are mixed. Score 5.1/10, moderate confidence.
Passes 6/8 gates (favorable risk/reward ratio, no SEC red flags, news events none recent, earnings proximity 74d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and clean insider activity. Suitability: moderate.
Recent developments
updated 2026-08-15Recent Developments — United Therapeutics Corporation
Latest news
- NEWS Is Now The Time To Put United Therapeutics (NASDAQ:UTHR) On Your Watchlist? - Moomoo — Moomoo neutral
- NEWS Is Now The Time To Put United Therapeutics (NASDAQ:UTHR) On Your Watchlist? - moomoo.com — moomoo.com neutral
- NEWS UTHR Looks 35.2% Overvalued on GF Value™ - GuruFocus — GuruFocus negative
- NEWS UTHR|United Therapeutics Corp|Price:525.965|Chg%:+1.265 - TradingKey — TradingKey neutral
- NEWS United Therapeutics chairperson & CEO Martine Rothblatt sells $5.4m in stock - Investing.com — Investing.com negative
Generated 2026-08-15T13:12:19Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHProductTyvaso DPI and Nebulized Tyvaso59%10-K Item 1: 'combined Tyvaso DPI and Nebulized Tyvaso net product sales, representing 59 percent...of our total revenues for the years ended December 31, 2025'
- HIGHCustomerAccredo and CVS Specialty10-K Item 1A: 'we derive substantially all our treprostinil-based revenues from sales to two distributors, Accredo and CVS Specialty'
- HIGHSupplierMannKind Corporation10-K Item 1A: 'We rely entirely on MannKind to manufacture Tyvaso DPI finished drug product and inhalers for us, with no plans to develop an alternate or backup supply arrangement'
- HIGHSupplierDEKA10-K Item 1A: 'We rely entirely on DEKA and its affiliates to manufacture the Remunity and RemunityPRO Pumps'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
2 floor-breakers
Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static
Revenue shrinking — -1.9% YoY. Growth thesis broken unless recovery story develops.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Momentum 1.9/10 is below the 5.0 floor at $499.73 — engine's falling-knife protection flags exit rather than catching a breakdown. Specifics: Concentration risk — Product: Tyvaso DPI and Nebulized Tyvaso (59.0%); Concentration risk — Customer: Accredo and CVS Specialty. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $476.08. Score 5.1/10, moderate confidence.
Take-profit target: $568.31 (+13.7% upside). Prior stop was $476.08. Stop-loss: $476.08.
Concentration risk — Product: Tyvaso DPI and Nebulized Tyvaso (59.0%); Concentration risk — Customer: Accredo and CVS Specialty; Weak growth.
United Therapeutics Corporation trades at a P/E of 18.0 (forward 16.6). TrendMatrix value score: 5.9/10. Verdict: Sell.
22 analysts cover UTHR with a consensus score of 4.1/5. Average price target: $653.
What does United Therapeutics Corporation do?United Therapeutics markets five therapies for pulmonary arterial hypertension and rare diseases — Tyvaso DPI,...
United Therapeutics markets five therapies for pulmonary arterial hypertension and rare diseases — Tyvaso DPI, Nebulized Tyvaso, Remodulin, Orenitram, and Unituxin — generating approximately $3.16 billion in total revenues in 2025. Tyvaso DPI and Nebulized Tyvaso together accounted for 59% of revenues; substantially all treprostinil revenues flow through two distributors, Accredo and CVS Specialty, with no FDA-approved backup manufacturing site for Orenitram or Unituxin.