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AZNAstraZeneca PLCHold5.7·$156.02-0.77%
HoldModerate Confidence
Investment thesis

A wide economic moat, strong margins at 17%, a strong Piotroski F-Score of 8/9, and a 3-of-4 earnings beat record underpin a high-quality franchise that offers 10.2% headroom to the target with a 2.3-to-1 risk/reward — the sole near-term drag is weakening price momentum, which keeps the setup in a holding pattern rather than an active buy.

Thesis pillars

  • Wide Moat Quality FranchiseStable
  • Earnings Beat Track RecordStable
  • Momentum Headwind Weakening Price ActionDeteriorating
  • +2 more pillars — see the Why tab for full reasoning

Full reasoning →

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AstraZeneca PLC (AZN) Stock Analysis

HoldQualityModerate Confidence

Healthcare · Drug Manufacturers - General

Hold if already holding. Not a fresh buy at $156.02, but acceptable to hold if already in. Reasons: Weak growth; Negative momentum.

AstraZeneca PLC, a biopharmaceutical company, focuses on the discovery, development, manufacture, and commercialization of prescription medicines. The company offers Imjudo, Datroway, Iressa, Tagrisso, Imfinzi, Lynparza, Calquence, Enhertu, Orpathys, Truqap, Zoladex, Faslodex,... Read more

$156.02+18.8% A.UpsideScore 5.7/10#7 of 16 Drug Manufacturers - General
QualityF-score8 / 9FCF yield2.01%
IncomeYield2.02%(5y avg 2.09%)Payout47.41%sustainable
Stop $147.97Target $185.91(analyst − 13%)A.R:R 3.5:1
Analyst target$213.69+37.0%10 analysts
$185.91our TP
$156.02price
$213.69mean
$240

Hold if already holding. Not a fresh buy at $156.02, but acceptable to hold if already in. Reasons: Weak growth; Negative momentum. Chart setup: No clear chart pattern; technical signals are mixed. Maintain position. Not compelling to add more. Score 5.7/10, moderate confidence.

Passes 6/7 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, earnings proximity 77d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: moderate.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-08-15
TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Fri, Oct 30, 202677d to earnings· next earnings call

Thesis

Rewards
Strong earnings beat streak (3/4)
Positive insider activity
Wide economic moat
Risks
Weak growth
Negative momentum

Key Metrics

P/E (TTM)23.8
P/E (Fwd)13.6
Mkt Cap$243.9B
EV/EBITDA13.6
Profit Mgn17.0%
ROE22.0%
Rev Growth6.4%
Beta0.21
Dividend2.02%
Rating analysts35

Quality Signals

Piotroski F8/9MoatWideCompounder

Options Flow

P/C1.12bearish
IV47%normal

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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About TrendMatrix. TrendMatrix is a publisher of general securities research and market commentary. We publish on a regular schedule. All content is the same for every subscriber in a tier — we do not provide personalized investment advice and we do not take into account any individual subscriber's financial situation, investment objectives, risk tolerance, tax situation, or holdings.

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Conflicts and positions. The TrendMatrix editorial team frequently holds personal long-term positions in securities discussed. We disclose positions held at the time of publication on each piece. We maintain a trading-window policy: we do not initiate or close positions in the same direction as a TrendMatrix publication within 24 hours before or 72 hours after publication.

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Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

2 floor-breakers

Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static

Macd
0.0
Obv
1.0
Ma Position
2.5
Volume
2.8
Rsi
3.5
Volume distribution (falling OBV)

Growth below the gate floor. Component breakdown shows what dragged the score down.static

Earnings Growth
2.5
Revenue Growth
4.1
GatesMomentum 2.0<4.5A.R:R 3.5 ≥ 1.5Insider activity: OKNo SEC red flagsEARNINGS PROXIMITY 77d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Moderate
RSI
33 · Neutral
20D MA 50D MA 200D MASupport $152.40Resistance $173.88

Price Targets

$148
$186
A.Upside+18.8%
A.R:R3.5:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! momentum at 2.0 (below the engine's 4.5 threshold)

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-10-30 (77d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is AZN stock a buy right now?

Hold if already holding. Not a fresh buy at $156.02, but acceptable to hold if already in. Reasons: Weak growth; Negative momentum. Chart setup: No clear chart pattern; technical signals are mixed. Maintain position. Not compelling to add more. Target $185.91 (+19.2%), stop $147.97 (−5.4%), A.R:R 3.5:1. Score 5.7/10, moderate confidence.

What is the AZN stock price target?

Take-profit target: $185.91 (+18.8% upside). Target $185.91 (+19.2%), stop $147.97 (−5.4%), A.R:R 3.5:1. Stop-loss: $147.97.

What are the risks of investing in AZN?

Weak growth; Negative momentum.

Is AZN overvalued or undervalued?

AstraZeneca PLC trades at a P/E of 23.8 (forward 13.6). TrendMatrix value score: 6.5/10. Verdict: Hold.

What do analysts say about AZN?

35 analysts cover AZN with a consensus score of 4.2/5. Average price target: $214.

What does AstraZeneca PLC do?AstraZeneca PLC, a biopharmaceutical company, focuses on the discovery, development, manufacture, and commercialization...

AstraZeneca PLC, a biopharmaceutical company, focuses on the discovery, development, manufacture, and commercialization of prescription medicines. The company offers Imjudo, Datroway, Iressa, Tagrisso, Imfinzi, Lynparza, Calquence, Enhertu, Orpathys, Truqap, Zoladex, Faslodex, Crestor, Andexxa, Onglyza, Symlin, XIGDUO XR, Atacand, Atacand HCT, Atacand Plus, Farxiga/Forxiga, Plendil, Modip, Splendil, Munobal, Flodil, Tenormin, Tenormine, Prenormine, Atenol, Zestril, Brilinta/Brilique, Komboglyze, Qtern, Wainua, Byetta, Lokelma, Seloken ZOK, Toprol-XL, Betaloc ZOK, XIGDUO, Accolate, Accoleit, Vanticon, Bricanyl Respules, Eklira Genuair/Tudorza/Bretaris, Pulmicort Turbuhaler, Symbicort Turbuhaler, Airsupra, Bricanyl Turbuhaler, Fasenra, Rhinocort, Tezspire, Bevespi Aerosphere, Daliresp/Daxas, Oxis Turbuhaler, Saphnelo, Breztri Aerosphere, Duaklir Genuair, Pulmicort Respules, and Symbicort pMDI. It also provides Beyfortus, Kavigale, Evusheld, Fluenz/FluMist, Synagis, Kanuma, Ultomiris, Koselugo, Voydeya, Soliris, Strensiq, Nexium, and other medicines. The company offers its products for ocology, cardiovascular, renal and metabolism, respiratory & immunology, vaccines and immune, and therapies rare diseases. It serves primary and specialty care physicians through distributors and local representative offices in the United Kingdom, the Americas, rest of Europe, Asia, Africa, and Australasia. It has a strategic agreement with Tempus and Pathos to develop the largest multimodal foundation model in oncology; CSPC Pharmaceutical Group Limited to advance the discovery and development of novel oral candidates, with the potential to treat diseases across multiple indications; and Nucs AI Inc. to develop AI-driven Response Prediction for Therapeutic Radioconjugates. The company was formerly known as Zeneca Group PLC and changed its name to AstraZeneca PLC in April 1999. AstraZeneca PLC was incorporated in 1992 and is headquartered in Cambridge, the United Kingdom.

Related stocks: LLY (Eli Lilly and Company) · BMY (Bristol-Myers Squibb Company) · AMGN (Amgen Inc.) · ABBV (AbbVie Inc.) · SNY (Sanofi)
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