Spyre Therapeutics is a clinical-stage biotech with strong price momentum, a breakout technical setup, and strong analyst sentiment at 8.6 average rating, but the company burns cash with a negative Piotroski F-Score of only 2 and its entire value rests on four early-stage drug programs with no revenue base.
Thesis pillars
- Pipeline Concentration Binary Risk→Stable
- Breakout Momentum Analyst Sentiment→Stable
- Cash Burn Quality Below Floor→Stable
- +1 more pillar — see the Why tab for full reasoning
Spyre Therapeutics, Inc. (SYRE) Stock Analysis
Range Bound setup
Healthcare · Biotechnology
Sell if holding. Engine safety override at $83.97: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10. Specifically: High short interest: 16%; Below-average business quality.
Spyre Therapeutics is a clinical-stage biotechnology company with no approved products, developing long-acting antibodies targeting α4β7, TL1A, and IL-23 for inflammatory bowel disease and rheumatic diseases. It had 102 employees and $756.5 million in cash and marketable... Read more
Sell if holding. Engine safety override at $83.97: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10. Specifically: High short interest: 16%; Below-average business quality. Chart setup: RSI 59 mid-range, Bollinger mid-band. Score 4.4/10, moderate confidence.
Passes 5/9 gates (positive momentum, news events none recent, earnings proximity 30d clear, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio and clean insider activity. Suitability: speculative.
About Spyre Therapeutics, Inc.
About Spyre Therapeutics, Inc.
Spyre Therapeutics advanced six investigational agents—SPY001 (anti-α4β7), SPY002 (anti-TL1A), SPY003 (anti-IL-23), and three pairwise fixed-dose combinations—into the SKYLINE Phase 2 platform trial in May 2025, targeting moderately to severely active ulcerative colitis, with Part A induction data expected in Q2 2026. The company held $756.5 million in cash, cash equivalents, and marketable securities at December 31, 2025, and reported a net loss of $155.2 million for the year, employing 102 full-time staff.
Spyre has no approved products and generates no revenue from sales; operations are funded through equity and debt financings. SPY001 demonstrated a pharmacokinetic profile supporting potential quarterly or twice-annual maintenance dosing based on Phase 1 data through eight months of follow-up; SPY002 and SPY072 showed complete suppression of free TL1A through up to 20-24 weeks at a single 100 mg dose. SPY003 data presented in February 2026 demonstrated comparable PK differentiation supporting quarterly or twice-annual dosing. All nonclinical and clinical manufacturing is outsourced to third parties, with WuXi Biologics supplying GMP manufacturing for the SPY001, SPY002, and SPY003 programs under a master services agreement running to October 2029. The Fiscal Year 2026 National Defense Authorization Act, signed December 18, 2025, includes BIOSECURE Act provisions that could limit engagement with certain foreign biotechnology manufacturers, prompting Spyre to accelerate supply chain redundancy outside China.
Show full overview
Spyre's near-term value is concentrated in two binary readout windows: SKYLINE Part A induction data for SPY001, SPY002, and SPY003 monotherapies expected in Q2 2026, and SKYWAY topline proof-of-concept data for SPY072 in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis expected in Q4 2026. The 10-K states the company is substantially dependent on the success of the SPY001, SPY002, SPY072 and SPY003 programs. Part B of SKYLINE—testing pairwise combinations including SPY120, SPY130, and SPY230—is not expected to yield induction data until 2027, leaving the clinical calendar heavily concentrated in the 2026 readout windows.
See also: Healthcare · Biotechnology
From Spyre Therapeutics, Inc.'s most recent 10-K filing, extracted June 11, 2026.
Recent developments
updated 2026-07-07Recent Developments — Spyre Therapeutics, Inc.
Latest news
- NEWS Spyre Therapeutics Files Prospectus For Offering Mixed Shelf; Terms Undisclosed — benzinga Jun 26, 2026 neutral
- NEWS What's Going On With Spyre Therapeutics Stock On Wednesday? — benzinga Jun 24, 2026 neutral
- NEWS FedEx, Cerebras Systems And Other Big Stocks Moving Lower In Wednesday’s Pre-Market Session — benzinga Jun 24, 2026 neutral
- NEWS Why Leifras Shares Are Trading Higher By Around 23%; Here Are 20 Stocks Moving Premarket — benzinga Jun 24, 2026 positive
- NEWS 12 Health Care Stocks Moving In Tuesday's After-Market Session — benzinga Jun 23, 2026 neutral
Generated 2026-07-07T11:31:44Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHpipelineSPY001, SPY002, SPY072 and SPY003 programs10-K Item 1A: 'We are substantially dependent on the success of the SPY001, SPY002, SPY072 and SPY003 programs'
- MEDIUMSupplierWuXi Biologics10-K Item 1: 'The WuXi Biologics MSA governs certain development activities and Good Manufacturing Practice ("GMP") manufacturing and testing for the SPY001, SPY002, and SPY003 programs'
Material Events(8-K, last 90d)
- 2026-05-29Item 5.02LOWDirector Peter Harwin resigned from the Board effective May 27, 2026. The resignation was not the result of any disagreement with the Company on any matter relating to the Company's operations, policies, or practices. No successor named.SEC filing →
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
2 floor-breakers
Quality below the gate floor. Component breakdown shows what dragged the score down.static
Volatile — 6.8% daily ATR makes tight stops impractical. Position-size conservatively.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $83.97: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10. Specifically: High short interest: 16%; Below-average business quality. Chart setup: RSI 59 mid-range, Bollinger mid-band. Prior stop was $82.53. Score 4.4/10, moderate confidence.
Take-profit target: $90.42 (+1.9% upside). Prior stop was $82.53. Stop-loss: $82.53.
Concentration risk — Pipeline: SPY001, SPY002, SPY072 and SPY003 programs; Target reached (1.9% upside); Quality below floor (1.2 < 4.0).
Spyre Therapeutics, Inc. trades at a P/E of N/A (forward -27.7). TrendMatrix value score: 5.0/10. Verdict: Sell.
23 analysts cover SYRE with a consensus score of 4.5/5. Average price target: $100.
What does Spyre Therapeutics, Inc. do?Spyre Therapeutics is a clinical-stage biotechnology company with no approved products, developing long-acting...
Spyre Therapeutics is a clinical-stage biotechnology company with no approved products, developing long-acting antibodies targeting α4β7, TL1A, and IL-23 for inflammatory bowel disease and rheumatic diseases. It had 102 employees and $756.5 million in cash and marketable securities at December 31, 2025, funding SKYLINE Phase 2 trials in UC and SKYWAY Phase 2 trials in rheumatic diseases.