Repligen Corporation carries exceptional business quality with a perfect Piotroski F-Score of 9/9 and 134% free cash flow conversion, and analysts see 21% upside, but the stock trades at a forward P/E of 51.4x while sitting below its 200-day moving average with elevated bearish options positioning.
Thesis pillars
- Exceptional Financial Quality→Stable
- Earnings Beat Streak→Stable
- Valuation Premium Risk↓Deteriorating
- +1 more pillar — see the Why tab for full reasoning
Repligen Corporation (RGEN) Stock Analysis
Healthcare · Medical Instruments & Supplies
Sell if holding. Analyst target reached at $189.68 — A.R:R is negative (-0.7) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Concentration risk — Supplier: single-source supplier (certain products).
Repligen develops and sells bioprocessing products across four franchises — Filtration, Chromatography, Process Analytics, and Proteins — used in manufacturing biological drugs including monoclonal antibodies, RNA therapeutics, and cell and gene therapies. Revenue comes... Read more
Sell if holding. Analyst target reached at $189.68 — A.R:R is negative (-0.7) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Concentration risk — Supplier: single-source supplier (certain products). Chart setup: No clear chart pattern; technical signals are mixed. Score 4.6/10, moderate confidence.
Passes 7/8 gates (positive momentum, clean insider activity, no SEC red flags, news events none recent, earnings proximity 38d clear, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio. Suitability: moderate.
About Repligen Corporation
About Repligen Corporation
Repligen's bioprocessing portfolio spans four franchises — Filtration (the largest, including fluid management), Chromatography, Process Analytics, and Proteins — sold to biopharmaceutical companies, CDMOs, and diagnostics companies through a global commercial team of approximately 390 employees. North America accounted for 49% of 2025 revenue, Europe for 34%, and Asia Pacific and the rest of the world for 17%, with no single country outside the United States exceeding 10% of revenues. The company employs approximately 2,000 people and operates 19 manufacturing sites in the United States, Europe, and Asia.
Repligen generates the majority of revenue from consumable and single-use products — including TangenX TFF cassettes, hollow fiber filters, OPUS pre-packed chromatography columns, and process analytics instruments — that biopharmaceutical customers repurchase each manufacturing campaign. Hardware such as KrosFlo TFF systems and KRM chromatography systems complement the consumable base. For the Proteins franchise, the company holds a long-term supply agreement with Purolite extended through 2032 to supply affinity ligands for Protein A resins used in monoclonal antibody purification. Competitors include Danaher Corporation (Cytiva), Thermo Fisher Scientific, MilliporeSigma, and Sartorius, which may market products at lower prices given their greater scale. Supply for the XCell ATF cell retention systems relies on a small number of qualified material suppliers; transitioning to alternatives would require revalidation and could disrupt operations.
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For certain products, Repligen relies on a single supplier, and the 10-K notes that transitioning to new suppliers would require altering operations, revalidating materials, and may involve interruptions in product availability. The XCell ATF franchise depends on a small pool of qualified material suppliers; if any qualified supplier exits or disrupts, revalidation requirements could delay product shipments. In December 2023, the company issued $600 million in 1.00% Convertible Senior Notes due 2028; the ability to service this obligation depends on continued cash generation from bioprocessing product sales, subject to economic, financial, and competitive factors.
See also: Healthcare · Medical Instruments & Supplies
From Repligen Corporation's most recent 10-K filing, extracted June 11, 2026.
Recent developments
updated 2026-09-26Recent Developments — Repligen Corporation
Latest news
- NEWS Repligen Corp (RGEN) Shares Surge 11.0% -- What GF Score of 87 T - GuruFocus — GuruFocus positive
- NEWS Is Repligen Corp (RGEN) a Bargain After 3.7% Drop? GF Value Says Undervalued - GuruFocus — GuruFocus positive
- NEWS Repligen to Buy BioLife Solutions for $31/Share in Cash, Stock >RGEN BLFS - Moomoo — Moomoo positive
- NEWS Repligen buys BioLife Solutions for $1.5 billion - grafa.com — grafa.com positive
- NEWS Repligen beefs up cell therapy business with $1.5 billion deal for BioLife - Reuters — Reuters positive
Generated 2026-09-26T04:42:01Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- MEDIUMGeographicNorth America49%10-K Item 1: 'North America ... 49'
- HIGHSuppliersingle-source supplier (certain products)10-K Item 1A: 'We rely on a limited number of suppliers or, for certain of our products, one supplier'
- MEDIUMSupplierXCell ATF material suppliers10-K Item 1A: 'only a small number of suppliers are currently qualified to supply materials for the XCell ATF® systems'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
3 floor-breakers
Priced at a premium — multiples above sector norms. Needs delivery on growth + margins to justify.static
Growth below the gate floor. Component breakdown shows what dragged the score down.static
Technicals below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Analyst target reached at $189.68 — A.R:R is negative (-0.7) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Concentration risk — Supplier: single-source supplier (certain products). Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $177.38. Score 4.6/10, moderate confidence.
Take-profit target: $218.13 (-10.1% upside). Prior stop was $177.38. Stop-loss: $177.38.
Concentration risk — Supplier: single-source supplier (certain products); Analyst target reached - limited upside remaining; Near 52-week high (1.5% away).
Repligen Corporation trades at a P/E of 250.9 (forward 71.9). TrendMatrix value score: 2.2/10. Verdict: Sell.
28 analysts cover RGEN with a consensus score of 4.1/5. Average price target: $189.
What does Repligen Corporation do?Repligen develops and sells bioprocessing products across four franchises — Filtration, Chromatography, Process...
Repligen develops and sells bioprocessing products across four franchises — Filtration, Chromatography, Process Analytics, and Proteins — used in manufacturing biological drugs including monoclonal antibodies, RNA therapeutics, and cell and gene therapies. Revenue comes predominantly from consumable and single-use product sales to biopharmaceutical companies and CDMOs, with approximately 2,000 employees and 19 manufacturing sites globally. North America represented 49% of 2025 revenue.