Personalis has already reached its analyst target with implied downside, quality metrics sit well below the engine's floor amid cash burn and declining revenue, and insiders have been steady net sellers — a stack of bearish signals despite a short-term overbought bounce.
Thesis pillars
- Analyst Target Already Reached→Stable
- Quality Cash Burn Below Floor→Stable
- Declining Revenue Trend→Stable
- +2 more pillars — see the Why tab for full reasoning
Personalis, Inc. (PSNL) Stock Analysis
Healthcare · Diagnostics & Research
Sell if holding. Engine safety override at $13.54: Quality below floor (2.0 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 2.7/10. Specifically: High short interest: 17%; Below-average business quality; Rich valuation.
Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD), therapy response and... Read more
Sell if holding. Engine safety override at $13.54: Quality below floor (2.0 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 2.7/10. Specifically: High short interest: 17%; Below-average business quality; Rich valuation. Chart setup: No clear chart pattern; technical signals are mixed. Score 2.7/10, high confidence.
Passes 6/8 gates (positive momentum, no SEC red flags, news events none recent, earnings proximity 32d clear, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio. Suitability: aggressive.
About Personalis, Inc.
About Personalis, Inc.
Personalis derives 90% of its revenue from the United States, with Europe and the rest of the world contributing 9% and 1%, respectively, for the year ended December 31, 2025. Its flagship NeXT Personal Dx liquid biopsy test, introduced in the fourth quarter of 2023, detects minimal residual disease and cancer recurrence, while two customers — Moderna and the VA MVP population-sequencing program — accounted for 22% and 17% of 2025 revenue.
Personalis sells testing services to pharmaceutical and biopharmaceutical companies for clinical trials and biomarker discovery, to diagnostics companies for whole exome sequencing, and directly to cancer patients through physicians, with Moderna, the VA MVP, and Natera together making up the largest named customers. The company's top five customers accounted for 62% of 2025 revenue, down from 81% in 2024, as the Natera relationship — once 30% of revenue in 2024 — fell to 8% in 2025 after the companies' MRD-testing partnership wound down. On the supply side, Personalis relies on Illumina as the sole supplier of the sequencers, reagents, and maintenance services its CLIA-certified Fremont, California laboratory needs to run every test. Commercial reach also depends on a 2023 co-commercialization agreement with Tempus, expanded in 2024 and again in July 2025 to cover biopharma customers and colorectal cancer, extending the partnership's term through November 2029.
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Personalis' laboratory operations run through a single point of failure: Illumina is the sole supplier of the sequencers, reagents, and maintenance services the Fremont lab needs, so any disruption to that relationship could halt testing capacity outright. That supply dependency compounds a customer-side risk the 10-K quantifies directly: Moderna and the VA MVP alone provided 39% of 2025 revenue, and the VA MVP's annual contracted orders have already fallen from $30.9 million in September 2020 to $10.0 million or less in most subsequent years, a decline the company attributes partly to federal cost-cutting and pandemic-era disruptions to veteran enrollment.
See also: Healthcare · Diagnostics & Research
From Personalis, Inc.'s most recent 10-K filing, extracted July 6, 2026.
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Rating Breakdown
4 floor-breakers
Revenue shrinking — -24.9% YoY. Growth thesis broken unless recovery story develops.static
Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static
Priced at a premium — multiples above sector norms. Needs delivery on growth + margins to justify.static
Unprofitable operations — net margin -148.1%. Quality floor flags this regardless of sector context.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $13.54: Quality below floor (2.0 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 2.7/10. Specifically: High short interest: 17%; Below-average business quality; Rich valuation. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $12.67. Score 2.7/10, high confidence.
Take-profit target: $13.96 (+2.5% upside). Prior stop was $12.67. Stop-loss: $12.67.
Target reached (-30.6% upside); Quality below floor (2.0 < 4.0).
Personalis, Inc. trades at a P/E of N/A (forward -15.2). TrendMatrix value score: 1.8/10. Verdict: Sell.
13 analysts cover PSNL with a consensus score of 4.2/5. Average price target: $11.
What does Personalis, Inc. do?Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and...
Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD), therapy response and recurrence monitoring in solid tumor cancers; and ImmunoID NeXT, a tissue-based service that combines whole exome and whole transcriptome sequencing data with advanced analytics to provide a multi-dimensional view of the tumor and the tumor microenvironment from a single sample. It also provides NeXT Personal Dx, a tumor-informed liquid biopsy test for the detection of MRD; and NeXT Dx, a tumor profiling test that is used to help select therapy for a cancer patient and identify potential clinical trials for a patient. In addition, the company performs whole exome sequencing of cancer tissue and matched blood samples for diagnostic companies as an input to their products; and whole genome sequencing on human samples for research projects, such as population sequencing initiatives. Its services are used by pharmaceutical companies for translational research, biomarker discovery, the development of personalized cancer therapies, and for clinical trials, as well as tests are used by physicians to detect residual or recurrent cancer in patients, monitor cancer response to therapy, and uncover insights for therapy selection. The company's customers include pharmaceutical companies, biopharmaceutical companies, diagnostics companies, universities, non-profits, government entities, and cancer patients. The company has strategic collaboration with Tempus AI, Inc. to bring testing to colorectal cancer patients. Personalis, Inc. was incorporated in 2011 and is headquartered in Fremont, California.