Pacira BioSciences trades below the $1 billion minimum investable universe threshold at $890 million market cap, carries a perfect 9/9 Piotroski F-Score with exceptional free cash flow conversion, but faces 24% short interest, a put/call ratio of 7.00, and capitulation-risk RSI near 30 — making this a sub-threshold speculative situation rather than a standard investment.
Thesis pillars
- Below Threshold Market Cap Flag↑Improving
- Perfect Piotroski Fcf Quality→Stable
- Elevated Put Call Short Interest Risk↑Improving
- +1 more pillar — see the Why tab for full reasoning
Pillars as of Jul 3, 2026, based on the 10-K filed Feb 26, 2026· older than 90 days
Pacira BioSciences, Inc. (PCRX) Stock Analysis
Healthcare · Drug Manufacturers - Specialty & Generic
Sell if holding. Analyst target reached at $36.40 — A.R:R is negative (-1.3) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Near 52-week high (0.7% away).
Pacira BioSciences is a biopharmaceutical company commercializing three non-opioid pain therapies: EXPAREL, a long-acting local analgesic for postsurgical pain that accounted for 79% of 2025 revenue; ZILRETTA, an extended-release corticosteroid injection for osteoarthritis knee... Read more
Sell if holding. Analyst target reached at $36.40 — A.R:R is negative (-1.3) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Near 52-week high (0.7% away). Chart setup: No clear chart pattern; technical signals are mixed. Score 4.9/10, moderate confidence.
Passes 6/9 gates (positive momentum, clean insider activity, no SEC red flags, news events none recent, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio and earnings proximity 0d<=7d. Suitability: aggressive.
About Pacira BioSciences, Inc.
About Pacira BioSciences, Inc.
Pacira BioSciences generated $575.1 million in net EXPAREL sales in 2025, up from $549.0 million in 2024, representing 79% of the company's total revenue, while ZILRETTA contributed $116.6 million (16% of revenue) and iovera° added $24.2 million. Under its January 2025 '5x30' strategic plan, Pacira reached 2.5 million patients treated in 2025 and is targeting more than 3 million patients annually, double-digit revenue growth, and a five-percentage-point gross margin improvement by 2030.
Pacira earns revenue from direct U.S. commercial sales of EXPAREL (bupivacaine liposome injectable suspension) across orthopedic, abdominal and colorectal, women's health, cardiothoracic, and pediatric surgical markets, plus ZILRETTA, a physician-administered, buy-and-bill corticosteroid injection for osteoarthritis knee pain now co-promoted with J&J MedTech under a July 2025 agreement. The company relies on third-party manufacturers, including Thermo Fisher and Amphenol, and stores finished goods across three warehouses maintained by two service providers, with EXPAREL requiring cold-chain distribution to preserve product integrity. Pacira has grown its portfolio through acquisitions, including Flexion Therapeutics in November 2021 and GQ Bio Therapeutics in February 2025, and continues developing PCRX-201, a Phase 2 gene therapy candidate for knee osteoarthritis from its high-capacity adenovirus vector platform.
Show full overview
Pacira's own risk factors state that the company's success depends primarily on its ability to commercialize EXPAREL and ZILRETTA, which together accounted for 95% of 2025 revenue (79% and 16%, respectively), leaving results highly sensitive to formulary approvals, third-party reimbursement rates, and the NOPAIN Act's new separate Medicare reimbursement for non-opioids like EXPAREL that took effect in January 2025. The company also faces active patent litigation against WhiteOak and Qilu over EXPAREL and ZILRETTA intellectual property, an outcome that could affect the exclusivity underpinning both products' pricing power.
See also: Healthcare · Drug Manufacturers - Specialty & Generic
From Pacira BioSciences, Inc.'s most recent 10-K filing, extracted July 6, 2026.
Recent developments
updated Oct 31, 2026Recent Developments — Pacira BioSciences, Inc.
Latest news
- NEWS PCRX Stock Alert: Halper Sadeh LLC is Investigating Whether Pacira BioSciences, Inc. is Obtaining a Fair Price for its S — Carroll County Mirror-Democrat Oct 31, 2026 negative
- NEWS Pacira BioSciences (PCRX) Holds Steady at $36.40 as Traders Eye Resistance - Oversold Bounce Ideas - https://www.dars.go — https://www.dars.gov.et/ Oct 27, 2026 neutral
- NEWS Oppenheimer Initiates Pacira Biosciences at Outperform With $32 Price Target - marketscreener.com — marketscreener.com Sep 23, 2026 positive
- NEWS Oppenheimer initiates Pacira stock with outperform rating - Investing.com India — Investing.com India Sep 23, 2026 positive
- NEWS Oppenheimer initiates Pacira stock with outperform rating - Investing.com — Investing.com Sep 23, 2026 positive
Latest item Oct 31, 2026 · Generated 2026-11-05T11:59:11Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. How we score · Editorial policy
Show full disclosure ▾Hide full disclosure ▴
About TrendMatrix. TrendMatrix is a publisher of general securities research and market commentary. We publish on a regular schedule. All content is the same for every subscriber in a tier — we do not provide personalized investment advice and we do not take into account any individual subscriber's financial situation, investment objectives, risk tolerance, tax situation, or holdings.
Not investment advice. TrendMatrix is not a registered investment adviser. Our content is for informational and educational purposes only. Consult your own licensed investment adviser, broker, or tax professional before making any investment decision.
Conflicts and positions. People who build TrendMatrix, or entities they control, may hold positions, long or short, in securities it covers, and may trade them at any time. Positions are not disclosed individually. Verdicts are generated by an automated model applied by the same rules to every covered stock, and are not adjusted for any position held by the people who build TrendMatrix. We do not accept payment from issuers for coverage.
No paid promotion. TrendMatrix does not accept payment from any issuer, broker, or third party in exchange for coverage of any security.
No fiduciary duty. No fiduciary, advisory, or agency relationship is created between you and TrendMatrix by reading our content or subscribing to our service.
Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.
Rating Breakdown
2 floor-breakers
Negative sentiment — recent news tone and/or analyst downgrades drag the composite below neutral.static
No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Analyst target reached at $36.40 — A.R:R is negative (-1.3) — price has exceeded the analyst target. Reward from here is too thin for a buy — the engine flags exit. Additional concerns: Near 52-week high (0.7% away). Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $36.28. Score 4.9/10, moderate confidence.
Analyst target $29.21 reached (−19.8% from $36.40); no take-profit level is published. Prior stop was $36.28. Stop-loss: $36.28.
Analyst target reached - limited upside remaining; Near 52-week high (0.7% away); V7 low-quality RISK_OFF penalty: -0.5 (Q=5.3).
Pacira BioSciences, Inc. trades at a P/E of 104.0 (forward 10.5). TrendMatrix value score: 6.2/10. Verdict: Sell.
14 analysts rate PCRX, with a consensus score of 2.6/5. 7 analysts publish price targets averaging $34.
What does Pacira BioSciences, Inc. do?Pacira BioSciences is a biopharmaceutical company commercializing three non-opioid pain therapies: EXPAREL, a...
Pacira BioSciences is a biopharmaceutical company commercializing three non-opioid pain therapies: EXPAREL, a long-acting local analgesic for postsurgical pain that accounted for 79% of 2025 revenue; ZILRETTA, an extended-release corticosteroid injection for osteoarthritis knee pain (16% of revenue); and iovera°, a cryoanalgesia device. The company is also advancing PCRX-201, a Phase 2 gene therapy for knee osteoarthritis from its proprietary high-capacity adenovirus vector platform. Under its '5x30' strategic plan launched in January 2025, Pacira aims to reach more than 3 million patients ann