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Guardant Health, Inc. (GH) Stock Analysis

SellModerate Confidence

Healthcare · Diagnostics & Research

Earnings in 7 days (2026-05-07). Expect elevated volatility around the report — consider waiting for post-earnings price action before new entries.

Sell if holding. Engine safety override at $83.90: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 3.4:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality; Negative price momentum.

Guardant Health is a precision oncology company offering liquid biopsy blood tests across all cancer care stages—Guardant360 CDx (advanced-stage therapy selection), Guardant Reveal (MRD detection), and Shield (FDA-approved colorectal cancer screening). Tests accounted for 94% of... Read more

$83.90+37.9% A.UpsideScore 5.6/10#5 of 25 Diagnostics & Research
Stop $77.91Target $115.50(analyst − 10%)A.R:R 3.4:1
Analyst target$128.33+53.0%21 analysts
$115.50our TP
$83.90price
$128.33mean
$180

Sell if holding. Engine safety override at $83.90: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 3.4:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality; Negative price momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Score 5.6/10, moderate confidence.

Passes 4/6 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, semi cycle peak clear). Fails on weak momentum and earnings proximity 7d<=7d. Suitability: aggressive.

Thesis

Rewards
No bull case signals
Risks
Concentration risk — Product: tests (94.0%)
Concentration risk — Customer: third-party commercial payers
Quality below floor (3.5 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-119.6
Mkt Cap$11.1B
EV/EBITDA-28.9
Profit Mgn-42.4%
ROE
Rev Growth39.4%
Beta1.65
DividendNone
Rating analysts34

Quality Signals

Piotroski F5/9

Options Flow

P/C0.01bullish
IV104%elevated
Max Pain$50-40.4% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHProducttests94%
    10-K Item 1A: 'our tests, which accounted for 94%, 94% and 91% of our revenue in the years ended December 31, 2025, 2024 and 2023, respectively'
  • HIGHCustomerthird-party commercial payers
    10-K Item 1A: 'We receive a substantial portion of our revenue from a limited number of third-party commercial payers'
  • LOWCustomerMedicare
    10-K Item 1A: 'Revenue attributable to Medicare accounted for more than 10% of our total revenue in each of the years ended December 31, 2025, 2024 and 2023.'

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

3 floor-breakers·1 ceiling hit

Momentum below the gate floor. Component breakdown shows what dragged the score down.static

Macd
0.0
Volume
0.0
Obv
1.0
Ma Position
4.0
Rsi
5.5
Volume distribution (falling OBV)Above 200-day MA

Unprofitable operations — net margin -42.4%. Quality floor flags this regardless of sector context.static

Roa
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Moat
5.0
Piotroski F
5.6
Current Ratio
8.2
Gross Margin
8.9
Cash-burning: FCF -9% of revenueNo competitive moat

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.0
Value Rank
0.8
Growth Rank
8.8
Industry growth leader
GatesMomentum 2.1<4.5EARNINGS PROXIMITY 7d<=7dA.R:R 3.4 ≥ 1.5Insider activity: OKNo SEC red flagsSEMI CYCLE PEAK CLEARSuitability: Aggressive
RSI
60 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $74.55Resistance $99.00

Price Targets

$78
$116
A.Upside+37.7%
A.R:R3.4:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (3.5 < 4.0)
! Momentum score 2.1/10 — below 4.5 minimum
! EARNINGS_PROXIMITY:7d<=7d

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-05-07 (7d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is GH stock a buy right now?

Sell if holding. Engine safety override at $83.90: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 3.4:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality; Negative price momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Prior stop was $77.91. Score 5.6/10, moderate confidence.

What is the GH stock price target?

Take-profit target: $115.50 (+37.9% upside). Prior stop was $77.91. Stop-loss: $77.91.

What are the risks of investing in GH?

Concentration risk — Product: tests (94.0%); Concentration risk — Customer: third-party commercial payers; Quality below floor (3.5 < 4.0).

Is GH overvalued or undervalued?

Guardant Health, Inc. trades at a P/E of N/A (forward -119.6). TrendMatrix value score: 6.4/10. Verdict: Sell.

What do analysts say about GH?

34 analysts cover GH with a consensus score of 4.3/5. Average price target: $128.

What does Guardant Health, Inc. do?Guardant Health is a precision oncology company offering liquid biopsy blood tests across all cancer care...

Guardant Health is a precision oncology company offering liquid biopsy blood tests across all cancer care stages—Guardant360 CDx (advanced-stage therapy selection), Guardant Reveal (MRD detection), and Shield (FDA-approved colorectal cancer screening). Tests accounted for 94% of 2025 revenue; the company remains unprofitable with a $416M net loss in 2025.

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