Guardant Health, Inc. (GH) Stock Analysis
Range Bound setup
Healthcare · Diagnostics & Research
Sell if holding. Engine safety override at $127.00: Quality below floor (3.7 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10. Specifically: High short interest: 10%; Below-average business quality; Rich valuation.
Guardant Health is a precision oncology company that develops and commercializes liquid biopsy tests (Guardant360, Shield, Guardant Infinity) for cancer detection, therapy selection, and monitoring. It earns revenue primarily from clinical test volumes reimbursed by Medicare and... Read more
Sell if holding. Engine safety override at $127.00: Quality below floor (3.7 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10. Specifically: High short interest: 10%; Below-average business quality; Rich valuation. Chart setup: RSI 50 mid-range, Bollinger mid-band. Score 5.3/10, moderate confidence.
Passes 6/8 gates (clean insider activity, no SEC red flags, news events none recent, earnings proximity 43d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and favorable risk/reward ratio. Suitability: aggressive.
About Guardant Health, Inc.
About Guardant Health, Inc.
Guardant360 CDx, the first FDA-approved liquid biopsy test for solid tumor mutation profiling and companion diagnostic use, and Shield, the first blood-based test approved for primary colorectal cancer screening and meeting Medicare coverage requirements, anchor Guardant Health's commercial portfolio. Tests represented 94% of total revenue in both 2024 and 2025, with biopharmaceutical collaborations making up the remainder. The company reported net losses of $416.3 million in 2025 against an accumulated deficit of $3.0 billion at year-end.
Guardant Health sells tests to oncologists, cancer centers, primary care physicians, and health systems through a U.S. direct sales force, and to biopharmaceutical companies for companion diagnostic development, retrospective testing, and clinical study enrollment. Clinical test revenue is subject to negotiated rates from contracted commercial payers and to variable reimbursement from non-contracted payers, which set their own rates and may retroactively recover prior payments — a pattern that has already occurred. Medicare accounted for more than 10% of total revenue in each of 2025, 2024, and 2023, and Guardant Health depends on a CMS laboratory date-of-service exception to bill Medicare directly in certain settings. Top-five biopharmaceutical customers contributed 11% of total revenue in 2025, down from 14% in 2023. Competition in liquid biopsy therapy selection includes Foundation Medicine (acquired by Roche), Caris Life Sciences, and Tempus AI; GRAIL and Exact Sciences compete in early cancer detection.
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Guardant Health's Medicare revenue — representing more than 10% of total revenue — exposes the company to CMS policy risk: if CMS repeals or curtails the laboratory date-of-service exception that allows molecular pathology labs to bill Medicare directly, revenue could materially decrease. Commercial payer risk compounds this exposure; non-contracted payers retain the right to retroactively review and recover prior payments, a risk that has already materialized and that could cause quarterly results to fall below guidance.
See also: Healthcare · Diagnostics & Research
From Guardant Health, Inc.'s most recent 10-K filing, extracted June 10, 2026.
Recent developments
updated 2026-06-17Recent Developments — Guardant Health, Inc.
Latest news
- NEWS RBC Capital Initiates Coverage On Guardant Health with Outperform Rating, Announces Price Target of $185 — benzinga Jun 12, 2026 positive
- NEWS Guardant Health Says FDA Approves Guardant360 CDx As Companion Diagnostic For Boehringer Ingelheim's HERNEXEOS — benzinga Jun 11, 2026 positive
- NEWS Mizuho Maintains Outperform on Guardant Health, Raises Price Target to $175 — benzinga Jun 8, 2026 positive
- NEWS Goldman Sachs Initiates Coverage On Guardant Health with Buy Rating, Announces Price Target of $165 — benzinga Jun 5, 2026 positive
- NEWS CrowdStrike To Gain 7%? Here Are 10 Top Analyst Forecasts For Tuesday — benzinga Jun 2, 2026 neutral
Generated 2026-06-17T09:02:26Z.
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Rating Breakdown
4 floor-breakers·1 ceiling hit
Priced at a premium — multiples above sector norms. Needs delivery on growth + margins to justify.static
Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static
Unprofitable operations — net margin -40.1%. Quality floor flags this regardless of sector context.static
Momentum below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
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Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $127.00: Quality below floor (3.7 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10. Specifically: High short interest: 10%; Below-average business quality; Rich valuation. Chart setup: RSI 50 mid-range, Bollinger mid-band. Prior stop was $118.43. Score 5.3/10, moderate confidence.
Take-profit target: $132.30 (+3.9% upside). Prior stop was $118.43. Stop-loss: $118.43.
Target reached (-0.4% upside); Quality below floor (3.7 < 4.0).
Guardant Health, Inc. trades at a P/E of N/A (forward -244.0). TrendMatrix value score: 2.4/10. Verdict: Sell.
32 analysts cover GH with a consensus score of 4.3/5. Average price target: $141.
What does Guardant Health, Inc. do?Guardant Health is a precision oncology company that develops and commercializes liquid biopsy tests (Guardant360,...
Guardant Health is a precision oncology company that develops and commercializes liquid biopsy tests (Guardant360, Shield, Guardant Infinity) for cancer detection, therapy selection, and monitoring. It earns revenue primarily from clinical test volumes reimbursed by Medicare and commercial insurers, and from biopharmaceutical research partnerships.