BeOne Medicines combines 36% revenue growth, a Piotroski F-Score of 9/9, a wide economic moat, and a Rule of 40 score of 51 with strong analyst conviction (54% upside consensus), but the stock is in a confirmed falling knife pattern with RSI at 22, a death cross in place, and BRUKINSA product concentration risk from a single revenue driver.
Thesis pillars
- Brukinsa Concentration Growth Engine↓Deteriorating
- Wide Moat Compounder Quality→Stable
- Falling Knife Technical Setup↓Deteriorating
- +1 more pillar — see the Why tab for full reasoning
BeOne Medicines Ltd. (ONC) Stock Analysis
Temporary headwind edge
Healthcare · Biotechnology
Wait for pullback to $314.02. Weak momentum; also insider activity concern — blocks BUY_NOW at $358.26. Engine's entry $314.02 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Concentration risk — Product: BRUKINSA; Thin upside margin: 8.6%.
BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total... Read more
Wait for pullback to $314.02. Weak momentum; also insider activity concern — blocks BUY_NOW at $358.26. Engine's entry $314.02 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Concentration risk — Product: BRUKINSA; Thin upside margin: 8.6%. Chart setup: No clear chart pattern; technical signals are mixed. Growth is cheap relative to earnings, but the technical setup has not yet produced a breakout above resistance (PEG 0.00, quality 7.7/10, growth 9.9/10). Score 6.3/10, moderate confidence.
Passes 5/7 gates (favorable risk/reward ratio, no SEC red flags, earnings proximity 61d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: speculative.
Recent developments
updated 2026-09-05Recent Developments — BeOne Medicines Ltd.
Latest news
- NEWS BeOne Medicines Targets Esophageal Cancer With New Tislelizumab Trial in Japan - TipRanks — TipRanks positive
- NEWS Lazard Asset Management LLC Buys 14,696 Shares of BeOne Medicines Ltd. - Sponsored ADR $ONC - MarketBeat — MarketBeat neutral
- NEWS ADAR1 Capital Management LLC Makes New Investment in BeOne Medicines Ltd. - Sponsored ADR $ONC - MarketBeat — MarketBeat neutral
- NEWS BeOne Medicines (ONC) Could Be 25% Undervalued After Its $300 Million Hopewell Expansion - simplywall.st — simplywall.st positive
- NEWS BeOne Medicines (ONC) Receives FDA Priority Review for Tevimbra Treatment - GuruFocus — GuruFocus positive
Generated 2026-09-05T22:02:20Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHProductBRUKINSA10-K Item 1: 'total global revenue of approximately $5.3 billion ... BRUKINSA generated $3.9 billion in sales in 2025'
- MEDIUMGeographicChina10-K Item 1A: 'which could have a material adverse effect on our business, financial condition and results of operations in China'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
1 floor-breaker·1 ceiling hit
Momentum below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Wait for pullback to $314.02. Weak momentum; also insider activity concern — blocks BUY_NOW at $358.26. Engine's entry $314.02 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Concentration risk — Product: BRUKINSA; Thin upside margin: 8.6%. Chart setup: No clear chart pattern; technical signals are mixed. Growth is cheap relative to earnings, but the technical setup has not yet produced a breakout above resistance (PEG 0.00, quality 7.7/10, growth 9.9/10). Target $388.94 (+8.6%), stop $296.54 (−20.8%), A.R:R 1.7:1. Score 6.3/10, moderate confidence.
Take-profit target: $388.94 (+8.6% upside). Target $388.94 (+8.6%), stop $296.54 (−20.8%), A.R:R 1.7:1. Stop-loss: $296.54.
Concentration risk — Product: BRUKINSA; Thin upside margin: 8.6%; Negative momentum.
BeOne Medicines Ltd. trades at a P/E of 64.9 (forward 34.8). TrendMatrix value score: 4.8/10. Verdict: Buy (Wait for Entry).
12 analysts cover ONC with a consensus score of 4.2/5. Average price target: $432.
What does BeOne Medicines Ltd. do?BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK...
BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total revenue in 2025, with BRUKINSA contributing $3.9 billion in sales, and employs nearly 12,000 people across research, clinical, and commercial operations.