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ONCBeOne Medicines Ltd.Buy Wait6.5·$263.34-1.81%
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BeOne Medicines Ltd. (ONC) Stock Analysis

Falling Knife setup · Temp Headwind edge

Buy WaitModerate Confidence

Healthcare · Biotechnology

Wait — supporting gate not met yet. Price is at or below entry $294.06 but weak momentum; below 200-day MA (death cross) still blocks BUY_NOW. Key risks: Concentration risk — Product: BRUKINSA; Negative momentum.

BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total... Read more

$263.34+43.9% A.UpsideScore 6.5/10#8 of 157 Biotechnology
QualityF-score9 / 9FCF yield3.35%
Entry $294.06(Support Atr Sticky)Stop $278.38Target $371.11(analyst − 10%)A.R:R 6.8:1
Analyst target$412.35+56.6%27 analysts
$371.11our TP
$263.34price
$412.35mean
$501

Wait — supporting gate not met yet. Price is at or below entry $294.06 but weak momentum; below 200-day MA (death cross) still blocks BUY_NOW. Key risks: Concentration risk — Product: BRUKINSA; Negative momentum. Chart setup: Death cross, below all MAs, RSI 22, MACD bearish. Growth is cheap relative to earnings, but the technical setup has not yet produced a breakout above resistance (PEG 0.00, quality 7.5/10, growth 10.0/10). Score 6.5/10, moderate confidence.

Passes 6/8 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, earnings proximity 49d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and death cross (50MA < 200MA). Suitability: moderate.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-06-17
TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Wed, Aug 5, 202649d to earnings· next earnings call

Thesis

Rewards
Strong earnings beat streak (3/4)
High-quality business
Strong growth profile
Risks
Concentration risk — Product: BRUKINSA
Negative momentum
Below 200-day MA

Key Metrics

P/E (TTM)59.8
P/E (Fwd)27.2
Mkt Cap$27.4B
EV/EBITDA31.1
Profit Mgn8.9%
ROE12.4%
Rev Growth35.5%
Beta0.49
DividendNone
Rating analysts12

Quality Signals

Piotroski F9/9MoatWideCompounder

Options Flow

P/C0.65bullish
IV53%elevated
Max Pain$360+36.7% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHProductBRUKINSA
    10-K Item 1: 'total global revenue of approximately $5.3 billion ... BRUKINSA generated $3.9 billion in sales in 2025'
  • MEDIUMGeographicChina
    10-K Item 1A: 'which could have a material adverse effect on our business, financial condition and results of operations in China'

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

1 floor-breaker·1 ceiling hit

Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static

Macd
0.0
Obv
1.0
Ma Position
1.5
Rsi
3.0
Volume
3.9
Capitulation risk (RSI 22, below 200MA)Volume distribution (falling OBV)Below 200-MA, MA slope flat
GatesMomentum 1.9<4.5Death cross (50MA < 200MA)A.R:R 6.8 ≥ 1.5Insider activity: OKNo SEC red flagsEARNINGS PROXIMITY 49d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARFalling KnifeSuitability: Moderate
RSI
22 · Oversold
20D MA 50D MA 200D MADEATH CROSSSupport $253.95Resistance $312.01

Price Targets

$278
$294
$371
A.Upside+40.9%
A.R:R6.8:1

Position Sizing

ConvictionHigh conviction
Suggested %0.9%
Max %1.8%
RegimeSteady

Risk Alerts

! momentum at 1.9 (below the engine's 4.5 threshold)
! Death cross — 50-day MA below 200-day MA

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-08-05 (49d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ONC stock a buy right now?

Wait — supporting gate not met yet. Price is at or below entry $294.06 but weak momentum; below 200-day MA (death cross) still blocks BUY_NOW. Key risks: Concentration risk — Product: BRUKINSA; Negative momentum. Chart setup: Death cross, below all MAs, RSI 22, MACD bearish. Growth is cheap relative to earnings, but the technical setup has not yet produced a breakout above resistance (PEG 0.00, quality 7.5/10, growth 10.0/10). Target $371.11 (+40.9%), stop $278.38 (−-5.4%), Setup A.R:R 9.8:1. Score 6.5/10, moderate confidence.

What is the ONC stock price target?

Take-profit target: $371.11 (+43.9% upside). Target $371.11 (+40.9%), stop $278.38 (−-5.4%), Setup A.R:R 9.8:1. Stop-loss: $278.38.

What are the risks of investing in ONC?

Concentration risk — Product: BRUKINSA; Negative momentum; Below 200-day MA.

Is ONC overvalued or undervalued?

BeOne Medicines Ltd. trades at a P/E of 59.8 (forward 27.2). TrendMatrix value score: 5.9/10. Verdict: Buy (Wait for Entry).

What do analysts say about ONC?

12 analysts cover ONC with a consensus score of 4.2/5. Average price target: $412.

What does BeOne Medicines Ltd. do?BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK...

BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total revenue in 2025, with BRUKINSA contributing $3.9 billion in sales, and employs nearly 12,000 people across research, clinical, and commercial operations.

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