BeOne Medicines combines 36% revenue growth, a Piotroski F-Score of 9/9, a wide economic moat, and a Rule of 40 score of 51 with strong analyst conviction (54% upside consensus), but the stock is in a confirmed falling knife pattern with RSI at 22, a death cross in place, and BRUKINSA product concentration risk from a single revenue driver.
Thesis pillars
- Brukinsa Concentration Growth Engine↓Deteriorating
- Wide Moat Compounder Quality→Stable
- Falling Knife Technical Setup↓Deteriorating
- +1 more pillar — see the Why tab for full reasoning
BeOne Medicines Ltd. (ONC) Stock Analysis
Breakout setup
Healthcare · Biotechnology
Wait for pullback to $343.13. At $362.53 the A.R:R is 1.1:1 — below the 1.5:1 minimum for BUY_NOW. Engine's entry $343.13 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Concentration risk — Product: BRUKINSA; Thin upside margin: 7.4%.
BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total... Read more
Wait for pullback to $343.13. At $362.53 the A.R:R is 1.1:1 — below the 1.5:1 minimum for BUY_NOW. Engine's entry $343.13 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Concentration risk — Product: BRUKINSA; Thin upside margin: 7.4%. Chart setup: Golden cross, above all MAs, RSI 53, MACD bullish. Growth is outpacing valuation and the technical setup has confirmed a breakout above resistance (PEG 0.00, quality 7.7/10, growth 9.9/10). Score 6.4/10, moderate confidence.
Passes 6/9 gates (positive momentum, no SEC red flags, news events none recent, earnings proximity 41d clear, semi cycle peak clear, materials cycle peak clear). Fails on favorable risk/reward ratio and clean insider activity. Suitability: speculative.
Recent developments
updated 2026-09-25Recent Developments — BeOne Medicines Ltd.
Latest news
- NEWS BeOne Medicines Targets Esophageal Cancer With New Tislelizumab Trial in Japan - TipRanks — TipRanks positive
- NEWS Lazard Asset Management LLC Buys 14,696 Shares of BeOne Medicines Ltd. - Sponsored ADR $ONC - MarketBeat — MarketBeat neutral
- NEWS ADAR1 Capital Management LLC Makes New Investment in BeOne Medicines Ltd. - Sponsored ADR $ONC - MarketBeat — MarketBeat neutral
- NEWS BeOne Medicines (ONC) Could Be 25% Undervalued After Its $300 Million Hopewell Expansion - simplywall.st — simplywall.st positive
- NEWS BeOne Medicines (ONC) Receives FDA Priority Review for Tevimbra Treatment - GuruFocus — GuruFocus positive
Generated 2026-09-25T20:57:26Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHProductBRUKINSA10-K Item 1: 'total global revenue of approximately $5.3 billion ... BRUKINSA generated $3.9 billion in sales in 2025'
- MEDIUMGeographicChina10-K Item 1A: 'which could have a material adverse effect on our business, financial condition and results of operations in China'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
1 ceiling hit
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Wait for pullback to $343.13. At $362.53 the A.R:R is 1.1:1 — below the 1.5:1 minimum for BUY_NOW. Engine's entry $343.13 (Atr Pullback Sticky) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risks: Concentration risk — Product: BRUKINSA; Thin upside margin: 7.4%. Chart setup: Golden cross, above all MAs, RSI 53, MACD bullish. Growth is outpacing valuation and the technical setup has confirmed a breakout above resistance (PEG 0.00, quality 7.7/10, growth 9.9/10). Target $389.52 (+7.4%), stop $325.08 (−11.5%), A.R:R 1.1:1. Score 6.4/10, moderate confidence.
Take-profit target: $389.52 (+7.4% upside). Target $389.52 (+7.4%), stop $325.08 (−11.5%), A.R:R 1.1:1. Stop-loss: $325.08.
Concentration risk — Product: BRUKINSA; Thin upside margin: 7.4%.
BeOne Medicines Ltd. trades at a P/E of 65.3 (forward 34.9). TrendMatrix value score: 4.8/10. Verdict: Buy (Wait for Entry).
12 analysts cover ONC with a consensus score of 4.2/5. Average price target: $433.
What does BeOne Medicines Ltd. do?BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK...
BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total revenue in 2025, with BRUKINSA contributing $3.9 billion in sales, and employs nearly 12,000 people across research, clinical, and commercial operations.