BeOne Medicines combines 36% revenue growth, a Piotroski F-Score of 9/9, a wide economic moat, and a Rule of 40 score of 51 with strong analyst conviction (54% upside consensus), but the stock is in a confirmed falling knife pattern with RSI at 22, a death cross in place, and BRUKINSA product concentration risk from a single revenue driver.
Thesis pillars
- Brukinsa Concentration Growth Engine↓Deteriorating
- Wide Moat Compounder Quality→Stable
- Falling Knife Technical Setup↓Deteriorating
- +1 more pillar — see the Why tab for full reasoning
BeOne Medicines Ltd. (ONC) Stock Analysis
Catalyst-Driven edge
Healthcare · Biotechnology
Wait for pullback to $345.44. Weak momentum — blocks BUY_NOW at $351.48. Engine's entry $345.44 (support + ATR (held)) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risk: Concentration risk — Product: BRUKINSA.
BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total... Read more
Wait for pullback to $345.44. Weak momentum — blocks BUY_NOW at $351.48. Engine's entry $345.44 (support + ATR (held)) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risk: Concentration risk — Product: BRUKINSA. Chart setup: No clear chart pattern; technical signals are mixed. Growth is cheap relative to earnings, but the technical setup has not yet produced a breakout above resistance (PEG 0.00, quality 7.7/10, growth 9.9/10). Score 6.5/10, moderate confidence.
Passes 8/9 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 22d clear, semi cycle peak clear, materials cycle peak clear). Suitability: speculative.
Recent developments
updated 2026-10-15Recent Developments — BeOne Medicines Ltd.
Latest news
- NEWS BeOne Medicines (NASDAQ:ONC) Insider Sells $11,318,704.12 in Stock - MarketBeat — MarketBeat negative
- NEWS BeOne Medicines (NASDAQ:ONC) Insider Sells $11,318,704.12 in Stock - marketbeat.com — marketbeat.com negative
- NEWS BeOne Medicines Targets Esophageal Cancer With New Tislelizumab Trial in Japan - TipRanks — TipRanks positive
- NEWS Lazard Asset Management LLC Buys 14,696 Shares of BeOne Medicines Ltd. - Sponsored ADR $ONC - MarketBeat — MarketBeat neutral
- NEWS ADAR1 Capital Management LLC Makes New Investment in BeOne Medicines Ltd. - Sponsored ADR $ONC - MarketBeat — MarketBeat neutral
Generated 2026-10-15T11:32:14Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHProductBRUKINSA10-K Item 1: 'total global revenue of approximately $5.3 billion ... BRUKINSA generated $3.9 billion in sales in 2025'
- MEDIUMGeographicChina10-K Item 1A: 'which could have a material adverse effect on our business, financial condition and results of operations in China'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
1 ceiling hit
Price Targets
Position Sizing
Analyst Consensus
Earnings
Verdict History
Frequently Asked Questions
Wait for pullback to $345.44. Weak momentum — blocks BUY_NOW at $351.48. Engine's entry $345.44 (support + ATR (held)) is the shallowest technical level that clears the 2:1 A.R:R minimum. Key risk: Concentration risk — Product: BRUKINSA. Chart setup: No clear chart pattern; technical signals are mixed. Growth is cheap relative to earnings, but the technical setup has not yet produced a breakout above resistance (PEG 0.00, quality 7.7/10, growth 9.9/10). Target $391.98 (+11.5%), stop $330.23 (−6.4%), A.R:R 2.0:1. Score 6.5/10, moderate confidence.
Take-profit target: $391.98 (+11.5% upside). Target $391.98 (+11.5%), stop $330.23 (−6.4%), A.R:R 2.0:1. Stop-loss: $330.23.
Concentration risk — Product: BRUKINSA.
BeOne Medicines Ltd. trades at a P/E of 62.4 (forward 34.1). TrendMatrix value score: 4.9/10. Verdict: Buy (Wait for Entry).
12 analysts cover ONC with a consensus score of 4.2/5. Average price target: $436.
What does BeOne Medicines Ltd. do?BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK...
BeOne Medicines discovers and commercializes oncology medicines globally, led by BRUKINSA (zanubrutinib), a BTK inhibitor approved in 77 markets, and TEVIMBRA (tislelizumab), an anti-PD-1 antibody approved in 51 markets. The company generated approximately $5.3 billion in total revenue in 2025, with BRUKINSA contributing $3.9 billion in sales, and employs nearly 12,000 people across research, clinical, and commercial operations.