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ANNXAnnexon, Inc.Sell5.4·$5.46-1.62%
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Annexon, Inc. (ANNX) Stock Analysis

Breakout setup · Inst Constrain edge

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $5.46: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.4/10 and A.R:R 7.3:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Elevated put/call ratio: 1.60; Below-average business quality.

Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. The company provides Tanruprubart, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of... Read more

$5.46+109.2% A.UpsideScore 5.4/10#71 of 258 Biotechnology
QualityF-score4 / 9FCF yield-12.00%
Stop $5.08Target $11.42(analyst − 13%)A.R:R 7.3:1
Analyst target$13.13+140.4%8 analysts
$11.42our TP
$5.46price
$13.13mean
$27

Sell if holding. Engine safety override at $5.46: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.4/10 and A.R:R 7.3:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Elevated put/call ratio: 1.60; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 69, MACD bullish. Score 5.4/10, moderate confidence.

Passes 8/8 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 40d clear, semi cycle peak clear, materials cycle peak clear). Suitability: speculative.

TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Thu, Aug 13, 202640d to earnings· next earnings call

Thesis

Rewards
No bull case signals
Risks
Quality below floor (1.8 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-5.9
Mkt Cap$895M
EV/EBITDA-3.4
Profit Mgn0.0%
ROE-87.6%
Rev Growth
Beta1.17
DividendNone
Rating analysts17

Quality Signals

Piotroski F4/9

Options Flow

P/C1.60bearish
IV86%elevated

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Methodology · Editorial policy & full disclaimer

Rating Breakdown

3 floor-breakers·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
4.4
Moat
4.8
Current Ratio
6.6
Cash-burning (FCF negative)No competitive moatQuality concerns

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.4
Value Rank
5.0
Growth Rank
5.0

Technicals below the gate floor. Component breakdown shows what dragged the score down.static

Bollinger
2.7
Support Resistance
3.7
52w Position
5.2
GatesMomentum 6.6>=5.5A.R:R 7.3 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 40d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARBreakoutSuitability: Speculative
RSI
69 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $4.46Resistance $6.04

Price Targets

$5
$11
A.Upside+109.2%
A.R:R7.3:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.8 < 4.0)

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-08-13 (40d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ANNX stock a buy right now?

Sell if holding. Engine safety override at $5.46: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.4/10 and A.R:R 7.3:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Elevated put/call ratio: 1.60; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 69, MACD bullish. Prior stop was $5.08. Score 5.4/10, moderate confidence.

What is the ANNX stock price target?

Take-profit target: $11.42 (+109.2% upside). Prior stop was $5.08. Stop-loss: $5.08.

What are the risks of investing in ANNX?

Quality below floor (1.8 < 4.0).

Is ANNX overvalued or undervalued?

Annexon, Inc. trades at a P/E of N/A (forward -5.9). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about ANNX?

17 analysts cover ANNX with a consensus score of 4.1/5. Average price target: $13.

What does Annexon, Inc. do?Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating...

Annexon, Inc., a clinical-stage biopharmaceutical company, discovers and develops medicines for treating inflammatory-related diseases. The company provides Tanruprubart, an investigational full-length monoclonal antibody, which is in Phase 3 clinical trial for the treatment of patients with guillain-barré syndrome; completed Phase II clinical trial for treating Huntington's disease; and in Phase 2a clinical trial for the treatment of amyotrophic lateral sclerosis. It is also developing ANX007, an antigen-binding fragment (Fab) that is in Phase 3 program for the treatment of patients with geographic atrophy; and ANX1502, a novel oral small molecule inhibitor, which is in Phase 1 clinical trials for autoimmune indications. In addition, it develops ANX009, a C1q-blocking Fab that is in Phase I clinical trial for treating patients with lupus nephritis. The company was incorporated in 2011 and is headquartered in Brisbane, California.

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