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ZBIOZenas BioPharma, Inc.Sell4.7·$17.92-4.22%
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Zenas BioPharma, Inc. (ZBIO) Stock Analysis

Recovery setup

SellVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $17.92: Quality below floor (1.5 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.7/10 and A.R:R 6.8:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 26%; Below-average business quality; Negative price momentum.

Zenas BioPharma, Inc., a clinical-stage biopharma company, engages in the development and commercialization of transformative immunology-based therapies. Its lead product candidate is obexelimab, a bifunctional monoclonal antibody designed to bind CD19 and Fc?RIIb for the... Read more

$17.92+101.5% A.UpsideScore 4.7/10#133 of 157 Biotechnology
QualityF-score4 / 9FCF yield-14.08%
Stop $16.92Target $36.65(analyst − 13%)A.R:R 6.8:1
Analyst target$42.13+135.1%8 analysts
$36.65our TP
$17.92price
$42.13mean
$55

Sell if holding. Engine safety override at $17.92: Quality below floor (1.5 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.7/10 and A.R:R 6.8:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 26%; Below-average business quality; Negative price momentum. Chart setup: Death cross but MACD improving, RSI 51. Score 4.7/10, moderate confidence.

Passes 7/8 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 57d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: aggressive.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-06-17
TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Wed, Aug 12, 202657d to earnings· next earnings call

Thesis

Rewards
No bull case signals
Risks
Quality below floor (1.5 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-8.3
Mkt Cap$1.2B
EV/EBITDA-2.9
Profit Mgn0.0%
ROE-137.1%
Rev Growth
Beta
DividendNone
Rating analysts14

Quality Signals

Piotroski F4/9

Options Flow

P/C1.00neutral
IV107%elevated
Max Pain$18-2.3% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

5 floor-breakers·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Moat
4.0
Piotroski F
4.4
Current Ratio
5.0
Cash-burning (FCF negative)No competitive moatQuality concerns

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.0
Value Rank
5.0
Growth Rank
5.0

Volatile — 7.7% daily ATR makes tight stops impractical. Position-size conservatively.static

Days To Cover
0.0
Volatility
0.0
Implied Vol
0.0
Short Interest
0.9
Max Pain Risk
5.0
Debt Equity
6.2
Put Call
6.7
High short interest justified: 26%High IV: 107%

Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static

Obv
1.0
Volume
1.4
Ma Position
2.2
Rsi
4.5
Macd
9.0
Volume distribution (falling OBV)Below 200-MA but MA still rising (+1.7%/30d) — pullback in uptrend, not confirmed weakness

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Earnings History
0.0
Surprise Avg
0.0
Erm
5.0
Earnings Timing
5.0
News Activity
8.0
Earnings concerns: 1B/3M
GatesMomentum 3.6<4.5A.R:R 6.8 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 57d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARRecoverySuitability: Aggressive
RSI
51 · Neutral
20D MA 50D MA 200D MADEATH CROSSSupport $16.77Resistance $20.87

Price Targets

$17
$37
A.Upside+104.5%
A.R:R6.8:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.5 < 4.0)
! momentum at 3.6 (below the engine's 4.5 threshold)

Earnings

B
M
M
M
1/4 beats
Next Earnings2026-08-12 (57d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ZBIO stock a buy right now?

Sell if holding. Engine safety override at $17.92: Quality below floor (1.5 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.7/10 and A.R:R 6.8:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 26%; Below-average business quality; Negative price momentum. Chart setup: Death cross but MACD improving, RSI 51. Prior stop was $16.92. Score 4.7/10, moderate confidence.

What is the ZBIO stock price target?

Take-profit target: $36.65 (+101.5% upside). Prior stop was $16.92. Stop-loss: $16.92.

What are the risks of investing in ZBIO?

Quality below floor (1.5 < 4.0).

Is ZBIO overvalued or undervalued?

Zenas BioPharma, Inc. trades at a P/E of N/A (forward -8.3). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about ZBIO?

14 analysts cover ZBIO with a consensus score of 4.4/5. Average price target: $42.

What does Zenas BioPharma, Inc. do?Zenas BioPharma, Inc., a clinical-stage biopharma company, engages in the development and commercialization of...

Zenas BioPharma, Inc., a clinical-stage biopharma company, engages in the development and commercialization of transformative immunology-based therapies. Its lead product candidate is obexelimab, a bifunctional monoclonal antibody designed to bind CD19 and Fc?RIIb for the treatment of various I&I diseases and various indications, including immunoglobulin G4-related disease, multiple sclerosis, and systemic lupus erythematosus. The company develops ZB002, an anti-TNFa monoclonal antibody; ZB004, a CTLA-4-Ig fusion protein designed to have an extended half-life versus; and ZB001, an anti-IGF-1R monoclonal antibody. The company was formerly known as Zenas BioPharma (Cayman) Limited and changed its name to Zenas BioPharma, Inc. in August 2023. The company was incorporated in 2019 and is headquartered in Waltham, Massachusetts.

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