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Relay Therapeutics, Inc. (RLAY) Stock Analysis

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $11.81: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.9/10 and A.R:R 3.9:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Below-average business quality.

Relay Therapeutics is a clinical-stage precision medicine company developing small molecule therapies using its Dynamo Motion-Based Drug Design platform. Lead candidate zovegalisib (RLY-2608), the first allosteric pan-mutant PI3Kα inhibitor, entered Phase 3 (ReDiscover-2 Trial)... Read more

$11.81+53.2% A.UpsideScore 4.9/10#105 of 157 Biotechnology
QualityF-score2 / 9FCF yield-5.23%
Stop $11.28Target $18.49(analyst − 13%)A.R:R 3.9:1
Analyst target$21.25+79.9%12 analysts
$18.49our TP
$11.81price
$21.25mean
$25

Sell if holding. Engine safety override at $11.81: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.9/10 and A.R:R 3.9:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Below-average business quality. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Score 4.9/10, moderate confidence.

Passes 6/7 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, earnings proximity 79d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: aggressive.

Recent Developments — Relay Therapeutics, Inc.

Generated 2026-05-20T21:06:21Z.

Thesis

Rewards
No bull case signals
Risks
Concentration risk — Pipeline: zovegalisib (RLY-2608)
Quality below floor (1.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-7.0
Mkt Cap$2.3B
EV/EBITDA-5.8
Profit Mgn0.0%
ROE-40.0%
Rev Growth-60.9%
Beta1.75
DividendNone
Rating analysts19

Quality Signals

Piotroski F2/9

Options Flow

P/C0.26bullish
IV129%elevated

Concentration Risks(10-K Item 1A)

  • HIGHpipelinezovegalisib (RLY-2608)
    10-K Item 1: 'We are advancing a pipeline of medicine candidates to address targets in precision oncology and genetic disease, including zovegalisib (RLY-2608), our lead product candidate'

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

3 floor-breakers·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
2.2
Moat
2.5
Current Ratio
5.0
Cash-burning: FCF -1135% of revenueNo competitive moatWeak Piotroski F-Score: 2/9Quality concerns

Volatile — 6.9% daily ATR makes tight stops impractical. Position-size conservatively.static

Volatility
0.0
Implied Vol
0.0
Debt Equity
0.1
Short Interest
1.8
Days To Cover
2.7
News Risk
4.0
Beta
4.2
Put Call
10.0
High short interest justified: 17%High IV: 129%Concentration risks: 1 HIGH (10-K Item 1A — sized via position_sizing, validated via buy_confidence)

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Growth Rank
1.6
Quality Rank
3.4
Value Rank
5.0
GatesMomentum 4.3<4.5A.R:R 3.9 ≥ 1.5Insider activity: OKNo SEC red flagsEARNINGS PROXIMITY 79d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Aggressive
RSI
43 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $11.63Resistance $17.15

Price Targets

$11
$18
A.Upside+56.6%
A.R:R3.9:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.2 < 4.0)
! Momentum score 4.3/10 — below 4.5 minimum

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-06 (79d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is RLAY stock a buy right now?

Sell if holding. Engine safety override at $11.81: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.9/10 and A.R:R 3.9:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Below-average business quality. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Prior stop was $11.28. Score 4.9/10, moderate confidence.

What is the RLAY stock price target?

Take-profit target: $18.49 (+53.2% upside). Prior stop was $11.28. Stop-loss: $11.28.

What are the risks of investing in RLAY?

Concentration risk — Pipeline: zovegalisib (RLY-2608); Quality below floor (1.2 < 4.0).

Is RLAY overvalued or undervalued?

Relay Therapeutics, Inc. trades at a P/E of N/A (forward -7.0). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about RLAY?

19 analysts cover RLAY with a consensus score of 4.3/5. Average price target: $21.

What does Relay Therapeutics, Inc. do?Relay Therapeutics is a clinical-stage precision medicine company developing small molecule therapies using its Dynamo...

Relay Therapeutics is a clinical-stage precision medicine company developing small molecule therapies using its Dynamo Motion-Based Drug Design platform. Lead candidate zovegalisib (RLY-2608), the first allosteric pan-mutant PI3Kα inhibitor, entered Phase 3 (ReDiscover-2 Trial) in Q2 2025 for HR+/HER2- PI3Kα-mutated breast cancer; FDA Breakthrough Therapy designation granted February 2026.

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