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Alumis Inc. (ALMS) Stock Analysis

Range Bound setup

SellVALUE-TRAP 2/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $23.52: Quality below floor (3.7 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.0/10 and A.R:R 3.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 18%; Elevated put/call ratio: 8.29; Below-average business quality.

Alumis is a clinical-stage biopharmaceutical company developing two TYK2 inhibitors: envudeucitinib (envu) in Phase 3 for plaque psoriasis with positive topline results in Q1 2026 and NDA filing planned for H2 2026, and A-005 in Phase 1 for neuroinflammatory diseases. The... Read more

$23.52+42.3% A.UpsideScore 5.0/10#82 of 158 Biotechnology
Stop $21.84Target $33.41(analyst − 13%)A.R:R 3.6:1
Analyst target$38.40+63.3%10 analysts
$33.41our TP
$23.52price
$38.40mean
$55

Sell if holding. Engine safety override at $23.52: Quality below floor (3.7 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.0/10 and A.R:R 3.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 18%; Elevated put/call ratio: 8.29; Below-average business quality. Chart setup: RSI 53 mid-range, Bollinger mid-band. Score 5.0/10, moderate confidence.

Passes 6/7 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 15d clear, semi cycle peak clear). Fails on weak momentum. Suitability: aggressive.

Thesis

Rewards
No bull case signals
Risks
Concentration risk — Product: envu
Quality below floor (3.7 < 4.0)
Value-trap signals (2/5): High leverage (D/E 3.8), Material insider selling (131 sells, 0.05% of cap)

Key Metrics

P/E (TTM)
P/E (Fwd)-7.1
Mkt Cap$2.9B
EV/EBITDA-6.0
Profit Mgn0.0%
ROE-86.7%
Rev Growth
Beta
DividendNone
Rating analysts17

Quality Signals

Piotroski F5/9

Options Flow

P/C8.29bearish
IV100%elevated
Max Pain$1-95.7% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHProductenvu
    10-K Item 1A: 'Our ability to achieve profitability in the future is dependent upon obtaining regulatory approval for and successfully commercializing our most advanced candidate, envu'

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

5 floor-breakers·1 ceiling hit

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.2
Value Rank
5.0
Growth Rank
5.0

Volatile — 5.8% daily ATR makes tight stops impractical. Position-size conservatively.static

Volatility
0.0
Put Call
0.0
Implied Vol
0.0
Short Interest
1.7
Max Pain Risk
3.0
Days To Cover
3.2
Debt Equity
9.5
High short interest justified: 18%Elevated put/call: 8.29High IV: 100%Above max pain $1Concentration risks: 1 HIGH (10-K Item 1A — sized via position_sizing, validated via buy_confidence)

Momentum below the gate floor. Component breakdown shows what dragged the score down.static

Volume
0.0
Obv
1.0
Macd
3.5
Ma Position
4.0
Rsi
5.5
Volume distribution (falling OBV)Above 200-day MA

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Net Margin
0.0
Fcf Quality
0.0
Moat
5.0
Piotroski F
5.6
Current Ratio
8.7
Gross Margin
10.0
Cash-burning: FCF -841% of revenueNo competitive moat

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Earnings History
0.0
Erm
5.0
Earnings Timing
5.0
Surprise Avg
5.6
Earnings concerns: 1B/3M
GatesMomentum 2.8<4.5A.R:R 3.6 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 15d clearSEMI CYCLE PEAK CLEARRange BoundSuitability: Aggressive
RSI
53 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $21.00Resistance $28.31

Price Targets

$22
$33
A.Upside+42.0%
A.R:R3.6:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (3.7 < 4.0)
! Value-trap signals (2/5): High leverage (D/E 3.8), Material insider selling (131 sells, 0.05% of cap)
! Momentum score 2.8/10 — below 4.5 minimum

Earnings

B
M
M
M
1/4 beats
Next Earnings2026-05-15 (15d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ALMS stock a buy right now?

Sell if holding. Engine safety override at $23.52: Quality below floor (3.7 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.0/10 and A.R:R 3.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 18%; Elevated put/call ratio: 8.29; Below-average business quality. Chart setup: RSI 53 mid-range, Bollinger mid-band. Prior stop was $21.84. Score 5.0/10, moderate confidence.

What is the ALMS stock price target?

Take-profit target: $33.41 (+42.3% upside). Prior stop was $21.84. Stop-loss: $21.84.

What are the risks of investing in ALMS?

Concentration risk — Product: envu; Quality below floor (3.7 < 4.0); Value-trap signals (2/5): High leverage (D/E 3.8), Material insider selling (131 sells, 0.05% of cap).

Is ALMS overvalued or undervalued?

Alumis Inc. trades at a P/E of N/A (forward -7.1). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about ALMS?

17 analysts cover ALMS with a consensus score of 4.4/5. Average price target: $38.

What does Alumis Inc. do?Alumis is a clinical-stage biopharmaceutical company developing two TYK2 inhibitors: envudeucitinib (envu) in Phase 3...

Alumis is a clinical-stage biopharmaceutical company developing two TYK2 inhibitors: envudeucitinib (envu) in Phase 3 for plaque psoriasis with positive topline results in Q1 2026 and NDA filing planned for H2 2026, and A-005 in Phase 1 for neuroinflammatory diseases. The company has no approved products and no revenue.

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