REC-4881
“10-K Item 1: 'the first clinical validation of the Recursion OS, with positive Phase 1b/2 results from our REC-4881 MEK1/2 inhibitor program in FAP'”
Updated
The most significant concentration Recursion Pharmaceuticals discloses is REC-4881, classified MEDIUM by disclosed size. Below: the full set from the latest 10-K — verbatim quotes, filing references, and a synthesis of what these exposures mean together.
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Source: Recursion Pharmaceuticals’s SEC Form 10-K filed — view the filing on SEC EDGAR ↗
Each card carries a disclosed-size chip (HIGH / MEDIUM / LOW — how large the exposure is as a share of revenue, not how dangerous it is) and a nature tag: Built-in(the company’s own model, geography, or products) or Outside party (an external customer, supplier, or distributor it relies on).
“10-K Item 1: 'the first clinical validation of the Recursion OS, with positive Phase 1b/2 results from our REC-4881 MEK1/2 inhibitor program in FAP'”
The company's disclosed concentration risk is limited to a single medium-share pipeline exposure: positive Phase 1b/2 results from the REC-4881 MEK1/2 inhibitor program in FAP represent the first clinical validation of the company's technology platform. The character of this exposure is mixed — it is partly structural, in that the company's entire business model is oriented around validating its AI-driven drug discovery platform through clinical outcomes, and partly idiosyncratic, in that the success or failure of any individual program carries specific binary risk. The mention of REC-4881 as the first disclosed clinical validation point suggests that the company is at an early stage of clinical proof-of-concept, and the medium-share size band indicates that while this program is meaningful, it is not the sole asset in the disclosed risk framework. The filing does not identify material customer, geographic, or supplier concentrations alongside this pipeline exposure, which is consistent with a pre-commercial discovery-stage organization whose dependencies are primarily internal — on the platform, on the team, and on the scientific and clinical execution. On balance, the concentration profile reflects a company at a pivotal stage of clinical de-risking. The primary monitoring variable is the clinical and regulatory trajectory of the pipeline, beginning with the REC-4881 program as the most concrete near-term data point. Investors should track additional pipeline readouts as the primary mechanism through which the concentration risk is either reduced — as more programs validate the platform — or elevated, should clinical setbacks call the broader approach into question.
For the engine’s reasoning on RXRX’s current verdict — including which dimensions drove the score — see the per-dimension breakdown.
| Symbol | Name | HIGH | MEDIUM | LOW | Total |
|---|---|---|---|---|---|
| ACAD | ACADIA Pharmaceuticals Inc. | 2 | 0 | 0 | 2 |
| ACLX | Arcellx, Inc. | 1 | 1 | 0 | 2 |
| AGIO | Agios Pharmaceuticals, Inc. | 1 | 0 | 0 | 1 |
| ALMS | Alumis Inc. | 1 | 0 | 0 | 1 |
| ADMA | ADMA Biologics Inc | 0 | 1 | 0 | 1 |
| RXRX● | Recursion Pharmaceuticals, Inc. | 0 | 1 | 0 | 1 |
Concentration counts reflect items disclosed in each peer’s most recent 10-K; disclosed-size classification uses TrendMatrix’s internal 10-K extraction taxonomy.