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Tyra Biosciences, Inc. (TYRA) Stock Analysis

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $33.78: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.5/10 and A.R:R 2.7:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 24%; Elevated put/call ratio: 50.50; Below-average business quality.

Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP platform, with lead program oral dabogratinib in Phase 2 trials for LG-UTUC (SURF303), IR NMIBC (SURF302), and achondroplasia (BEACH301). Two additional clinical... Read more

$33.78+31.7% A.UpsideScore 5.5/10#46 of 157 Biotechnology
QualityF-score2 / 9FCF yield-2.99%
Stop $31.42Target $44.50(analyst − 13%)A.R:R 2.7:1
Analyst target$51.15+51.4%11 analysts
$44.50our TP
$33.78price
$51.15mean
$60

Sell if holding. Engine safety override at $33.78: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.5/10 and A.R:R 2.7:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 24%; Elevated put/call ratio: 50.50; Below-average business quality. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Score 5.5/10, moderate confidence.

Passes 9/10 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost analyst 0.33, news boost analyst cluster(6), earnings proximity 85d clear, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.

Recent Developments — Tyra Biosciences, Inc.

Generated 2026-05-20T20:21:22Z.

Thesis

Rewards
Recent Analyst detected in news
Recent Analyst Cluster(6) detected in news
Risks
Quality below floor (1.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-11.9
Mkt Cap$2.0B
EV/EBITDA-11.5
Profit Mgn0.0%
ROE-36.9%
Rev Growth
Beta0.79
DividendNone
Rating analysts20

Quality Signals

Piotroski F2/9

Options Flow

P/C50.50bearish
IV86%elevated
Max Pain$35+3.6% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

1 floor-breaker·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
2.2
Moat
3.2
Current Ratio
5.0
Cash-burning (FCF negative)No competitive moatWeak Piotroski F-Score: 2/9Quality concerns
GatesMomentum 4.8<5.5 (soft — BUY_NOW allowed but watch)Momentum 4.8>=4.5A.R:R 2.7 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS BOOST ANALYST 0.33NEWS BOOST ANALYST CLUSTER(6)EARNINGS PROXIMITY 85d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Aggressive
RSI
50 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $32.26Resistance $38.63

Price Targets

$31
$45
A.Upside+31.7%
A.R:R2.7:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.2 < 4.0)

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-13 (85d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is TYRA stock a buy right now?

Sell if holding. Engine safety override at $33.78: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.5/10 and A.R:R 2.7:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 24%; Elevated put/call ratio: 50.50; Below-average business quality. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Prior stop was $31.42. Score 5.5/10, moderate confidence.

What is the TYRA stock price target?

Take-profit target: $44.50 (+31.7% upside). Prior stop was $31.42. Stop-loss: $31.42.

What are the risks of investing in TYRA?

Quality below floor (1.2 < 4.0).

Is TYRA overvalued or undervalued?

Tyra Biosciences, Inc. trades at a P/E of N/A (forward -11.9). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about TYRA?

20 analysts cover TYRA with a consensus score of 4.4/5. Average price target: $51.

What does Tyra Biosciences, Inc. do?Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP...

Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP platform, with lead program oral dabogratinib in Phase 2 trials for LG-UTUC (SURF303), IR NMIBC (SURF302), and achondroplasia (BEACH301). Two additional clinical programs, TYRA-430 (FGFR4, Phase 1 for HCC) and TYRA-200 (FGFR1/2/3, Phase 1 for resistant ICC), round out the pipeline.

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