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TYRATyra Biosciences, Inc.Sell5.3·$26.18-2.13%
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Tyra Biosciences, Inc. (TYRA) Stock Analysis

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $26.18: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 25%; Below-average business quality; Negative price momentum.

Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP platform, with lead program oral dabogratinib in Phase 2 trials for LG-UTUC (SURF303), IR NMIBC (SURF302), and achondroplasia (BEACH301). Two additional clinical... Read more

$26.18+69.9% A.UpsideScore 5.3/10#66 of 157 Biotechnology
QualityF-score2 / 9FCF yield-3.78%
Stop $24.46Target $44.50(analyst − 13%)A.R:R 5.2:1
Analyst target$51.15+95.4%11 analysts
$44.50our TP
$26.18price
$51.15mean
$60

Sell if holding. Engine safety override at $26.18: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 25%; Below-average business quality; Negative price momentum. Chart setup: No clear chart pattern; technical signals are mixed. Score 5.3/10, moderate confidence.

Passes 7/8 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 65d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: aggressive.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-06-09

Recent Developments — Tyra Biosciences, Inc.

Generated 2026-06-09T22:16:36Z.

TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Thu, Aug 13, 202665d to earnings· next earnings call

Thesis

Rewards
No bull case signals
Risks
Quality below floor (1.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-9.4
Mkt Cap$1.6B
EV/EBITDA-8.5
Profit Mgn0.0%
ROE-36.9%
Rev Growth
Beta0.75
DividendNone
Rating analysts21

Quality Signals

Piotroski F2/9

Options Flow

IV104%elevated
Max Pain$25-4.5% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

4 floor-breakers·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
2.2
Moat
3.2
Current Ratio
5.0
Cash-burning (FCF negative)No competitive moatWeak Piotroski F-Score: 2/9Quality concerns

Volatile — 6.8% daily ATR makes tight stops impractical. Position-size conservatively.static

Volatility
0.0
Implied Vol
0.0
Short Interest
1.0
Days To Cover
1.3
Debt Equity
4.1
Max Pain Risk
5.0
Beta
8.5
High short interest justified: 25%High IV: 104%

Momentum below the gate floor. Component breakdown shows what dragged the score down.static

Macd
0.0
Obv
1.0
Ma Position
4.0
Volume
4.3
Rsi
8.9
Oversold in uptrend (RSI 17)Volume distribution (falling OBV)Above 200-day MA

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Surprise Avg
1.6
Earnings History
3.3
Erm
5.0
Earnings Timing
5.0
Earnings concerns: 2B/2M
GatesMomentum 3.6<4.5A.R:R 5.2 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 65d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Aggressive
RSI
17 · Oversold
20D MA 50D MA 200D MAGOLDEN CROSSSupport $25.22Resistance $37.27

Price Targets

$24
$45
A.Upside+70.0%
A.R:R5.2:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.2 < 4.0)
! momentum at 3.6 (below the engine's 4.5 threshold)

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-13 (65d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is TYRA stock a buy right now?

Sell if holding. Engine safety override at $26.18: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.3/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 25%; Below-average business quality; Negative price momentum. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $24.46. Score 5.3/10, moderate confidence.

What is the TYRA stock price target?

Take-profit target: $44.50 (+69.9% upside). Prior stop was $24.46. Stop-loss: $24.46.

What are the risks of investing in TYRA?

Quality below floor (1.2 < 4.0).

Is TYRA overvalued or undervalued?

Tyra Biosciences, Inc. trades at a P/E of N/A (forward -9.4). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about TYRA?

21 analysts cover TYRA with a consensus score of 4.3/5. Average price target: $51.

What does Tyra Biosciences, Inc. do?Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP...

Tyra Biosciences is a clinical-stage oncology company developing oral FGFR inhibitors using its proprietary SNÅP platform, with lead program oral dabogratinib in Phase 2 trials for LG-UTUC (SURF303), IR NMIBC (SURF302), and achondroplasia (BEACH301). Two additional clinical programs, TYRA-430 (FGFR4, Phase 1 for HCC) and TYRA-200 (FGFR1/2/3, Phase 1 for resistant ICC), round out the pipeline.

Related stocks: AUPH (Aurinia Pharmaceuticals Inc) · ADMA (ADMA Biologics Inc) · HRMY (Harmony Biosciences Holdings, I) · TGTX (TG Therapeutics, Inc.) · HALO (Halozyme Therapeutics, Inc.)
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