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Taysha Gene Therapies, Inc. (TSHA) Stock Analysis

SellVALUE-TRAP 2/5Moderate Confidence

Healthcare · Biotechnology

Earnings in 6 days (2026-05-06). Expect elevated volatility around the report — consider waiting for post-earnings price action before new entries.

Sell if holding. Engine safety override at $6.51: Quality below floor (3.3 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 6.1/10 and A.R:R 3.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Elevated put/call ratio: 3.07; Below-average business quality.

Taysha Gene Therapies, Inc., a clinical-stage biotechnology company, focuses on developing and commercializing adeno-associated virus-based gene therapies for the treatment of severe monogenic diseases of the central nervous system. The company primarily develops TSHA-120 for... Read more

$6.51+54.8% A.UpsideScore 6.1/10#15 of 158 Biotechnology
Stop $6.05Target $10.07(analyst − 13%)A.R:R 3.6:1
Analyst target$11.57+77.7%14 analysts
$10.07our TP
$6.51price
$11.57mean
$19

Sell if holding. Engine safety override at $6.51: Quality below floor (3.3 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 6.1/10 and A.R:R 3.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Elevated put/call ratio: 3.07; Below-average business quality. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Score 6.1/10, moderate confidence.

Passes 4/6 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, semi cycle peak clear). Fails on weak momentum and earnings proximity 6d<=7d. Suitability: aggressive.

Thesis

Rewards
No bull case signals
Risks
Quality below floor (3.3 < 4.0)
Value-trap signals (2/5): Margin compression (op margin -9.4%), Material insider selling (9 sells, 0.05% of cap)

Key Metrics

P/E (TTM)
P/E (Fwd)-15.4
Mkt Cap$1.8B
EV/EBITDA-14.2
Profit Mgn0.0%
ROE-68.5%
Rev Growth171.3%
Beta1.08
DividendNone
Rating analysts20

Quality Signals

Piotroski F6/9

Options Flow

P/C3.07bearish
IV124%elevated
Max Pain$1-84.6% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

3 floor-breakers·3 ceiling hits

Volatile — 7.1% daily ATR makes tight stops impractical. Position-size conservatively.static

Days To Cover
0.0
Volatility
0.0
Put Call
0.0
Implied Vol
0.0
Max Pain Risk
3.0
Short Interest
3.1
Beta
6.7
Debt Equity
8.9
Elevated put/call: 3.07High IV: 124%Above max pain $1

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Net Margin
0.0
Fcf Quality
0.0
Rule Of 40
3.0
Current Ratio
5.0
Moat
5.0
Piotroski F
6.7
Gross Margin
10.0
Cash-burning: FCF -580% of revenueNo competitive moatRule of 40: -409 (fail)

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.8
Value Rank
5.0
Growth Rank
9.1
Industry growth leader
GatesMomentum 4.3<4.5EARNINGS PROXIMITY 6d<=7dA.R:R 3.6 ≥ 1.5Insider activity: OKNo SEC red flagsSEMI CYCLE PEAK CLEARSuitability: Aggressive
RSI
77 · Overbought
20D MA 50D MA 200D MAGOLDEN CROSSSupport $4.16Resistance $6.76

Price Targets

$6
$10
A.Upside+54.7%
A.R:R3.6:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (3.3 < 4.0)
! Value-trap signals (2/5): Margin compression (op margin -9.4%), Material insider selling (9 sells, 0.05% of cap)
! Momentum score 4.3/10 — below 4.5 minimum

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-05-06 (6d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is TSHA stock a buy right now?

Sell if holding. Engine safety override at $6.51: Quality below floor (3.3 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 6.1/10 and A.R:R 3.6:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Elevated put/call ratio: 3.07; Below-average business quality. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Prior stop was $6.05. Score 6.1/10, moderate confidence.

What is the TSHA stock price target?

Take-profit target: $10.07 (+54.8% upside). Prior stop was $6.05. Stop-loss: $6.05.

What are the risks of investing in TSHA?

Quality below floor (3.3 < 4.0); Value-trap signals (2/5): Margin compression (op margin -9.4%), Material insider selling (9 sells, 0.05% of cap).

Is TSHA overvalued or undervalued?

Taysha Gene Therapies, Inc. trades at a P/E of N/A (forward -15.4). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about TSHA?

20 analysts cover TSHA with a consensus score of 4.3/5. Average price target: $12.

What does Taysha Gene Therapies, Inc. do?Taysha Gene Therapies, Inc., a clinical-stage biotechnology company, focuses on developing and commercializing...

Taysha Gene Therapies, Inc., a clinical-stage biotechnology company, focuses on developing and commercializing adeno-associated virus-based gene therapies for the treatment of severe monogenic diseases of the central nervous system. The company primarily develops TSHA-120 for the treatment of giant axonal neuropathy; TSHA-102 for the treatment of Rett syndrome; TSHA-121 for the treatment of CLN7 disease; TSHA-118 for the treatment of CLN1 disease; TSHA-105 for the treatment of SLC13A5 deficiency; TSHA-113 for the treatment of tauopathies; TSHA-106 for the treatment of angelman syndrome; and TSHA-114 for the treatment of fragile X syndrome. The company has research, collaboration, and license agreement with The University of Texas Southwestern Medical Center. Taysha Gene Therapies, Inc. was incorporated in 2019 and is headquartered in Dallas, Texas.

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