Shattuck Labs shows a wide risk/reward asymmetry and large analyst-implied upside, but quality sits far below the engine's floor on extreme cash burn and the stock is technically overbought.
Thesis pillars
- Large Analyst Upside↓Deteriorating
- Wide Risk Reward Asymmetry→Stable
- Quality Floor Extreme Cash Burn↑Improving
- +1 more pillar — see the Why tab for full reasoning
Pillars as of Jul 5, 2026, based on the 10-K filed Mar 5, 2026
Shattuck Labs, Inc. (STTK) Stock Analysis
Inst Constrain edge
Healthcare · Biotechnology
Sell if holding. Engine safety override at $5.56: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 11.0:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 11%; Below-average business quality; Negative price momentum.
Shattuck Labs is a clinical-stage biotechnology company developing DR3-blocking antibodies for inflammatory and immune-mediated diseases, led by SL-325, a monoclonal antibody designed to block the DR3/TL1A signaling pathway implicated in ulcerative colitis and Crohn's disease.... Read more
Sell if holding. Engine safety override at $5.56: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 11.0:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 11%; Below-average business quality; Negative price momentum. Chart setup: No clear chart pattern; technical signals are mixed. Score 5.6/10, moderate confidence.
Passes 5/8 gates (favorable risk/reward ratio, clean insider activity, news events none recent, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: speculative.
About Shattuck Labs, Inc.
About Shattuck Labs, Inc.
Shattuck Labs' lead product candidate, SL-325, a DR3-blocking monoclonal antibody, is advancing through a Phase 1 trial in healthy volunteers that the company expects to complete in the second quarter of 2026, ahead of a randomized, placebo-controlled Phase 2 trial in Crohn's disease patients planned for the third quarter of 2026. The company has generated no product revenue and is also developing SL-425, a half-life-extended version of SL-325, alongside preclinical DR3-targeting bispecific antibodies.
Shattuck's strategy is to block the DR3 receptor rather than its ligand TL1A, arguing that DR3's stable expression on lymphocytes allows more complete pathway blockade than the TL1A-blocking antibodies tulisokibart, duvakitug, and afimkibart, each of which has already shown 23% to 28% placebo-adjusted clinical remission rates in third-party Phase 2 trials for ulcerative colitis and Crohn's disease. Those same TL1A-blocking antibodies have also shown anti-drug antibody formation in more than 64% of treated subjects in third-party trials, a side effect Shattuck says its DR3-targeting mechanism is designed to avoid. The inflammatory bowel disease market Shattuck is targeting is projected to grow from $23 billion in 2023 to $34 billion by 2030.
Show full overview
Shattuck's near-term value depends entirely on a single mechanism-of-action bet across its whole pipeline: SL-325, SL-425, and the company's preclinical bispecific antibody candidates are all built around blocking the same DR3 receptor, so a safety or efficacy failure specific to DR3 blockade — rather than to any one molecule — could compromise every program at once. The company's own comparison data shows two third-party TL1A-directed bispecific antibodies, AMG966 and RO7837195, produced nearly 100% anti-drug antibody formation after a single dose in Phase 1 trials, underscoring how immunogenicity failures in this pathway have historically hit entire modalities rather than individual molecules.
See also: Healthcare · Biotechnology
From Shattuck Labs, Inc.'s most recent 10-K filing, extracted July 6, 2026.
Recent developments
updated 2026-11-02Recent Developments — Shattuck Labs, Inc.
Latest news
- NEWS Evercore Initiates Coverage on Shattuck Labs with Buy Rating — fiscal.ai Oct 21, 2026 positive
- NEWS UBS Initiates Coverage On Shattuck Labs with Buy Rating, Announces Price Target of $17 — benzinga Oct 12, 2026 positive
- NEWS Wedbush Maintains Outperform on Shattuck Labs, Raises Price Target to $14 — benzinga Oct 2, 2026 positive
- NEWS Abbott To Rally Over 31%? Here Are 10 Top Analyst Forecasts For Friday — benzinga Oct 2, 2026 positive
- NEWS Needham Maintains Buy on Shattuck Labs, Raises Price Target to $19 — benzinga Oct 2, 2026 positive
Generated 2026-11-02T11:53:16Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHpipelineSL-325 / DR3 platform10-K Item 1: 'our lead program, SL-325, a potentially first-in-class DR3 blocking antibody'
Material Events(8-K, last 90d)
- 2026-06-02Item 5.02LOWStockholders approved an amendment and restatement of the 2020 Equity Incentive Plan at the May 28, 2026 Annual Meeting, increasing shares available by 1,691,082 and extending the plan's term to March 23, 2036; a routine equity-plan action, not a departure.SEC filing →
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. How we score · Editorial policy
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Rating Breakdown
2 floor-breakers·1 ceiling hit
Quality below the gate floor. Component breakdown shows what dragged the score down.static
Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $5.56: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.6/10 and A.R:R 11.0:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 11%; Below-average business quality; Negative price momentum. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $5.17. Score 5.6/10, moderate confidence.
Analyst target: $13.40 (+141.0% upside). Prior stop was $5.17. Stop-loss: $5.17.
Concentration risk — Pipeline: SL-325 / DR3 platform; Quality below floor (1.8 < 4.0).
Shattuck Labs, Inc. trades at a P/E of N/A (forward -10.8). TrendMatrix value score: 9.0/10. Verdict: Sell.
17 analysts cover STTK with a consensus score of 4.3/5. Average price target: $15.
What does Shattuck Labs, Inc. do?Shattuck Labs is a clinical-stage biotechnology company developing DR3-blocking antibodies for inflammatory and...
Shattuck Labs is a clinical-stage biotechnology company developing DR3-blocking antibodies for inflammatory and immune-mediated diseases, led by SL-325, a monoclonal antibody designed to block the DR3/TL1A signaling pathway implicated in ulcerative colitis and Crohn's disease. SL-325 is in an ongoing Phase 1 trial in healthy volunteers expected to complete enrollment in the second quarter of 2026, ahead of a planned Phase 2 trial in Crohn's disease patients in the third quarter of 2026. The company has generated no product revenue to date.