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Arcus Biosciences, Inc. (RCUS) Stock Analysis

SellVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $22.86: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.0/10 and A.R:R 3.0:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Below-average business quality; Negative price momentum.

Arcus Biosciences is a late clinical-stage biopharmaceutical company developing differentiated oncology and inflammation molecules, with lead programs casdatifan (HIF-2α, two Phase 3 trials in ccRCC), quemliclustat (CD73, Phase 3 in pancreatic cancer), and... Read more

$22.86+32.2% A.UpsideScore 4.0/10#148 of 157 Biotechnology
QualityF-score3 / 9FCF yield-5.30%
Stop $21.93Target $30.29(analyst − 13%)A.R:R 3.0:1
Analyst target$34.82+52.3%11 analysts
$30.29our TP
$22.86price
$34.82mean
$47

Sell if holding. Engine safety override at $22.86: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.0/10 and A.R:R 3.0:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Below-average business quality; Negative price momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Score 4.0/10, moderate confidence.

Passes 7/8 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost analyst 0.70, earnings proximity 78d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: aggressive.

Recent Developments — Arcus Biosciences, Inc.

Generated 2026-05-20T21:06:21Z.

Thesis

Rewards
Recent Analyst detected in news
Risks
Concentration risk — Counterparty: Gilead
Concentration risk — Supplier: WuXi Biologics
Quality below floor (2.7 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-7.4
Mkt Cap$2.9B
EV/EBITDA-5.7
Profit Mgn-156.4%
ROE-70.0%
Rev Growth-39.3%
Beta0.87
DividendNone
Rating analysts18

Quality Signals

Piotroski F3/9

Options Flow

P/C0.12bullish
IV78%elevated
Max Pain$15-34.4% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHcounterpartyGilead
    10-K Item 1A: 'We expect to depend on our collaboration with Gilead for the research, development, manufacture and commercialization of certain of our investigational products. If this collaboration is not successful, our business could be adversely affected.'
  • HIGHSupplierWuXi Biologics
    10-K Item 1: 'we agreed, as part of the WuXi PD-1 Agreement, that WuXi Biologics would be our exclusive manufacturer of zimberelimab drug substance with respect to clinical and commercial supplies until a certain number of years after marketing approval'

Material Events(8-K, last 90d)

  • 2026-03-23Item 5.02MEDIUM
    On March 17, 2026, Jennifer Jarrett (Chief Operating Officer) resigned effective March 30, 2026, to pursue other opportunities. She will provide advisory services through June 30, 2026. No successor named. No disagreement cited.
    SEC filing →

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

4 floor-breakers·1 ceiling hit

Revenue shrinking — -39.3% YoY. Growth thesis broken unless recovery story develops.static

Revenue Growth
0.0
Declining revenue: -39%
Low model confidence on this dimension (33%).

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.4
Growth Rank
2.0
Value Rank
4.0

Momentum below the gate floor. Component breakdown shows what dragged the score down.static

Macd
0.0
Volume
0.0
Obv
1.0
Ma Position
4.0
Rsi
5.5
Volume distribution (falling OBV)Above 200-day MA

Unprofitable operations — net margin -156.4%. Quality floor flags this regardless of sector context.static

Roe
0.0
Roa
0.0
Fcf Quality
0.0
Piotroski F
3.3
Moat
4.0
Current Ratio
9.0
Cash-burning: FCF -66% of revenueNo competitive moatWeak Piotroski F-Score: 3/9Quality concerns
GatesMomentum 2.1<4.5A.R:R 3.0 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS BOOST ANALYST 0.70EARNINGS PROXIMITY 78d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Aggressive
RSI
41 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $22.61Resistance $28.72

Price Targets

$22
$30
A.Upside+32.5%
A.R:R3.0:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (2.7 < 4.0)
! Momentum score 2.1/10 — below 4.5 minimum

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-05 (78d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is RCUS stock a buy right now?

Sell if holding. Engine safety override at $22.86: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.0/10 and A.R:R 3.0:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 14%; Below-average business quality; Negative price momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Prior stop was $21.93. Score 4.0/10, moderate confidence.

What is the RCUS stock price target?

Take-profit target: $30.29 (+32.2% upside). Prior stop was $21.93. Stop-loss: $21.93.

What are the risks of investing in RCUS?

Concentration risk — Counterparty: Gilead; Concentration risk — Supplier: WuXi Biologics; Quality below floor (2.7 < 4.0).

Is RCUS overvalued or undervalued?

Arcus Biosciences, Inc. trades at a P/E of N/A (forward -7.4). TrendMatrix value score: 6.1/10. Verdict: Sell.

What do analysts say about RCUS?

18 analysts cover RCUS with a consensus score of 4.1/5. Average price target: $35.

What does Arcus Biosciences, Inc. do?Arcus Biosciences is a late clinical-stage biopharmaceutical company developing differentiated oncology and...

Arcus Biosciences is a late clinical-stage biopharmaceutical company developing differentiated oncology and inflammation molecules, with lead programs casdatifan (HIF-2α, two Phase 3 trials in ccRCC), quemliclustat (CD73, Phase 3 in pancreatic cancer), and domvanalimab/zimberelimab (anti-TIGIT/PD-1, Phase 3 in NSCLC). The Gilead collaboration funds a significant portion of development costs and controls ex-U.S. commercialization rights for quemliclustat, domvanalimab, and zimberelimab. The company has no approved products and generates revenue primarily from collaboration payments.

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