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uniQure N.V. (QURE) Stock Analysis

Recovery setup

SellModerate Confidence

Healthcare · Biotechnology

Earnings in 5 days (2026-05-05). Expect elevated volatility around the report — consider waiting for post-earnings price action before new entries.

Sell if holding. Engine safety override at $18.71: Quality below floor (1.9 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 18%; Below-average business quality; Below long-term trend.

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding. Its lead product candidate... Read more

$18.71+78.3% A.UpsideScore 4.4/10#133 of 158 Biotechnology
Stop $17.39Target $33.34(analyst − 13%)A.R:R 5.2:1
Analyst target$38.33+104.8%11 analysts
$33.34our TP
$18.71price
$38.33mean
$9
$96

Sell if holding. Engine safety override at $18.71: Quality below floor (1.9 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 18%; Below-average business quality; Below long-term trend. Chart setup: Death cross but MACD improving, RSI 66. Score 4.4/10, moderate confidence.

Passes 4/6 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, semi cycle peak clear). Fails on weak momentum and earnings proximity 5d<=7d. Suitability: aggressive.

Thesis

Rewards
No bull case signals
Risks
Quality below floor (1.9 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-6.2
Mkt Cap$1.1B
EV/EBITDA-5.8
Profit Mgn0.0%
ROE-207.1%
Rev Growth6.6%
Beta0.75
DividendNone
Rating analysts21

Quality Signals

Piotroski F3/9

Options Flow

P/C0.93neutral
IV142%elevated
Max Pain$8-57.2% vs spot

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

3 floor-breakers·1 ceiling hit

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
0.0
Value Rank
0.1
Growth Rank
3.3

Technicals below the gate floor. Component breakdown shows what dragged the score down.static

52w Position
0.0
Bollinger
0.6
Support Resistance
0.9
Gap
3.0
Extreme gap up (7.4%) - may pull back

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roa
0.0
Gross Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
3.3
Current Ratio
5.0
Moat
5.0
Cash-burning: FCF -663% of revenueNo competitive moatWeak Piotroski F-Score: 3/9Quality concerns
GatesMomentum 4.2<4.5EARNINGS PROXIMITY 5d<=7dA.R:R 5.2 ≥ 1.5Insider activity: OKNo SEC red flagsSEMI CYCLE PEAK CLEARRecoverySuitability: Aggressive
RSI
66 · Neutral
20D MA 50D MA 200D MADEATH CROSSSupport $13.21Resistance $19.24

Price Targets

$17
$33
A.Upside+78.2%
A.R:R5.2:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.9 < 4.0)
! Momentum score 4.2/10 — below 4.5 minimum
! EARNINGS_PROXIMITY:5d<=7d

Earnings

B
B
B
M
3/4 beats
Next Earnings2026-05-05 (5d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is QURE stock a buy right now?

Sell if holding. Engine safety override at $18.71: Quality below floor (1.9 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 18%; Below-average business quality; Below long-term trend. Chart setup: Death cross but MACD improving, RSI 66. Prior stop was $17.39. Score 4.4/10, moderate confidence.

What is the QURE stock price target?

Take-profit target: $33.34 (+78.3% upside). Prior stop was $17.39. Stop-loss: $17.39.

What are the risks of investing in QURE?

Quality below floor (1.9 < 4.0).

Is QURE overvalued or undervalued?

uniQure N.V. trades at a P/E of N/A (forward -6.2). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about QURE?

21 analysts cover QURE with a consensus score of 4.0/5. Average price target: $38.

What does uniQure N.V. do?uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States....

uniQure N.V. develops treatments for patients suffering from rare and other devastating diseases in the United States. The company offers HEMGENIX that allows people living with hemophilia B to produce factor IX, which can lower the risk of bleeding. Its lead product candidate is AMT-130, a gene therapy candidate, which is in Phase I/II clinical study for the treatment of Huntington's disease. The company also develops AMT-260, which is in Phase I/IIa clinical trial for the treatment of mesial temporal lobe epilepsy; AMT-162, which is in Phase I/IIa clinical trial to treat superoxide dismutase enzyme-amyotrophic lateral sclerosis; and AMT-191, an investigational gene therapy candidate which is in phase I/IIa clinical trial for the treatment of fabry disease. It has a licensing agreement with Apic Bio to develop, manufacture, and commercialize intrathecally administered investigational gene therapy for ALS caused by mutations in SOD-1; and development and commercial supply agreement with CLS Bhering. uniQure N.V. was founded in 1998 and is headquartered in Amsterdam, the Netherlands.

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