Intellia Therapeutics, Inc. (NTLA) Stock Analysis
Breakout setup
Healthcare · Biotechnology
Sell if holding. Engine safety override at $14.46: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.0/10 and A.R:R 4.3:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 44%; Below-average business quality.
Intellia Therapeutics is a pre-commercial CRISPR gene editing company with two Phase 3 programs: lonvo-z for hereditary angioedema (HAE) and nex-z for ATTR amyloidosis, both designed as one-time in vivo treatments. The planned U.S. commercial launch for lonvo-z targets the first... Read more
Sell if holding. Engine safety override at $14.46: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.0/10 and A.R:R 4.3:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 44%; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 56, MACD bullish. Score 4.0/10, high confidence.
Passes 8/8 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost analyst 0.70, earnings proximity 51d clear, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.
About Intellia Therapeutics, Inc.
About Intellia Therapeutics, Inc.
Intellia Therapeutics is advancing two in vivo CRISPR therapies in Phase 3: lonvo-z for hereditary angioedema (HAE), with topline data from the 80-patient HAELO study expected mid-2026 and BLA submission planned for the second half of 2026; and nex-z for ATTR amyloidosis, with the MAGNITUDE Phase 3 trial (more than 650 enrolled patients for ATTR-CM) on FDA clinical hold since October 29, 2025, while the MAGNITUDE-2 study for ATTRv-PN had its hold lifted in January 2026 with enrollment expected to complete in the second half of 2026.
Intellia generates pre-commercial revenue primarily through collaboration arrangements. Nex-z is co-developed with Regeneron Pharmaceuticals, which shares approximately 25% of worldwide development costs and commercial profits under the ATTR co-development and co-promotion agreement; Intellia serves as the clinical and commercial lead. Under the 2016 Regeneron Agreement, Intellia is eligible for up to $320 million per in vivo target in development and commercial milestone payments plus mid-single-digit royalties on future sales. Lonvo-z is wholly owned. Additional revenue flows from licensing arrangements with AvenCell Therapeutics (ex vivo CAR-T programs) and Kyverna Therapeutics (allogeneic CD19 CAR-T for autoimmune disease). No genome editing in vivo therapy has been approved in the U.S., EU, or other key jurisdictions, and neither lonvo-z nor nex-z has received marketing authorization.
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The company's near-term value depends on two binary clinical readouts. Lonvo-z's HAELO Phase 3 primary endpoint — HAE attacks from week 5 through week 28 — is due mid-2026; a missed endpoint would eliminate the planned H1 2027 commercial launch and BLA submission timeline. For nex-z, the MAGNITUDE Phase 3 trial for ATTR-CM remains on FDA clinical hold following a Grade 4 liver injury and patient death reported in October 2025; Intellia has stated it cannot predict when the MAGNITUDE trial may resume, and failure to resolve the hold could prevent commercialization of the ATTR-CM indication, the larger of the two ATTR patient populations.
See also: Healthcare · Biotechnology
From Intellia Therapeutics, Inc.'s most recent 10-K filing, extracted June 11, 2026.
Recent developments
updated 2026-06-17Recent Developments — Intellia Therapeutics, Inc.
Latest news
- NEWS Citizens Reiterates Market Outperform on Intellia Therapeutics, Maintains $30 Price Target — benzinga Jun 15, 2026 positive
- NEWS Wedbush Reiterates Neutral on Intellia Therapeutics, Maintains $12 Price Target — benzinga Jun 15, 2026 neutral
- NEWS Intellia's One-Time Gene Editing Therapy Gains Ground Against Rivals In Rare Swelling Disorder — benzinga Jun 15, 2026 positive
- NEWS HC Wainwright & Co. Reiterates Buy on Intellia Therapeutics, Maintains $25 Price Target — benzinga Jun 15, 2026 positive
- NEWS Reported Saturday, Intellia Therapeutics' Lonvo-z Achieves 87% Attack Reduction And 62% Attack-Free Rate In Phase 3 HAEL — benzinga Jun 15, 2026 positive
Generated 2026-06-17T09:07:23Z.
Upcoming dated catalysts
Thesis
Key Metrics
Quality Signals
Options Flow
Concentration Risks(10-K Item 1A)
- HIGHpipelinelonvo-z (HAE)10-K Item 1: 'Lonvo-z and nex-z are currently in Phase 3 clinical development, and we are preparing for the planned commercial launch of lonvo-z in the first half of 2027'
- HIGHpipelinenex-z (ATTR amyloidosis)10-K Item 1A: 'the FDA placed a clinical hold on the IND applications for the MAGNITUDE and MAGNITUDE-2 Phase 3 clinical trials ... a patient who was dosed with nex-z in the MAGNITUDE trial'
Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.
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Rating Breakdown
4 floor-breakers
Revenue shrinking — -9.5% YoY. Growth thesis broken unless recovery story develops.static
Technicals below the gate floor. Component breakdown shows what dragged the score down.static
Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static
Quality below the gate floor. Component breakdown shows what dragged the score down.static
Price Targets
Position Sizing
Risk Alerts
Earnings
Verdict History
Frequently Asked Questions
Sell if holding. Engine safety override at $14.46: a dimension score below its floor triggers a hard block regardless of the otherwise-positive setup — overall score 4.0/10 and A.R:R 4.3:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 44%; Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 56, MACD bullish. Prior stop was $13.53. Score 4.0/10, high confidence.
Take-profit target: $23.97 (+64.7% upside). Prior stop was $13.53. Stop-loss: $13.53.
Concentration risk — Pipeline: lonvo-z (HAE); Concentration risk — Pipeline: nex-z (ATTR amyloidosis); Quality below floor (1.8 < 4.0).
Intellia Therapeutics, Inc. trades at a P/E of N/A (forward -8.3). TrendMatrix value score: 5.4/10. Verdict: Sell.
28 analysts cover NTLA with a consensus score of 3.6/5. Average price target: $27.
What does Intellia Therapeutics, Inc. do?Intellia Therapeutics is a pre-commercial CRISPR gene editing company with two Phase 3 programs: lonvo-z for hereditary...
Intellia Therapeutics is a pre-commercial CRISPR gene editing company with two Phase 3 programs: lonvo-z for hereditary angioedema (HAE) and nex-z for ATTR amyloidosis, both designed as one-time in vivo treatments. The planned U.S. commercial launch for lonvo-z targets the first half of 2027; revenue currently comes from collaboration arrangements including a cost- and profit-sharing agreement with Regeneron for nex-z.