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Iovance Biotherapeutics, Inc. (IOVA) Stock Analysis

Range Bound setup

SellVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $3.46: Quality below floor (3.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10 and A.R:R 8.1:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 28%; Below-average business quality; Negative price momentum.

Iovance Biotherapeutics is a commercial-stage biopharmaceutical company selling Amtagvi (lifileucel), the first approved TIL cell therapy for advanced melanoma, and Proleukin (aldesleukin). Revenue from Amtagvi infusions is recognized upon infusion; Proleukin sells through... Read more

$3.46+121.4% A.UpsideScore 5.7/10#35 of 157 Biotechnology
QualityF-score4 / 9FCF yield-9.85%
Stop $3.22Target $7.66(analyst − 13%)A.R:R 8.1:1
Analyst target$8.80+154.3%10 analysts
$7.66our TP
$3.46price
$8.80mean
$14

Sell if holding. Engine safety override at $3.46: Quality below floor (3.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10 and A.R:R 8.1:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 28%; Below-average business quality; Negative price momentum. Chart setup: RSI 54 mid-range, Bollinger mid-band. Score 5.7/10, moderate confidence.

Passes 7/8 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 79d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum. Suitability: aggressive.

Recent Developments — Iovance Biotherapeutics, Inc.

Generated 2026-05-20T21:06:21Z.

Thesis

Rewards
No bull case signals
Risks
Quality below floor (3.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-10.1
Mkt Cap$1.5B
EV/EBITDA-3.9
Profit Mgn-123.9%
ROE-47.5%
Rev Growth44.8%
Beta0.69
DividendNone
Rating analysts17

Quality Signals

Piotroski F4/9

Options Flow

P/C0.71neutral
IV95%elevated

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

4 floor-breakers·1 ceiling hit

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Surprise Avg
0.0
Earnings History
1.1
Erm
5.0
Earnings Timing
5.0
Earnings concerns: 1B/2M

Momentum below the gate floor. Component breakdown shows what dragged the score down.static

Volume
0.3
Obv
1.0
Macd
3.5
Ma Position
4.0
Rsi
5.5
Volume distribution (falling OBV)Above 200-day MA

Volatile — 7.7% daily ATR makes tight stops impractical. Position-size conservatively.static

Volatility
0.0
Implied Vol
0.0
Debt Equity
0.0
Short Interest
0.7
Days To Cover
2.1
Put Call
8.6
Beta
8.9
High short interest justified: 28%High IV: 95%

Clinical-stage biotech: losses expected pre-commercialisation. Quality floor doesn't distinguish R&D investment from operational decay — components above tell the real story.static

Roe
0.0
Roa
0.0
Fcf Quality
0.0
Gross Margin
3.9
Piotroski F
4.4
Moat
5.0
Current Ratio
9.4
Cash-burning: FCF -52% of revenueNo competitive moat
GatesMomentum 2.9<4.5A.R:R 8.1 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 79d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARRange BoundSuitability: Aggressive
RSI
54 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $3.27Resistance $4.15

Price Targets

$3
$8
A.Upside+121.4%
A.R:R8.1:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (3.2 < 4.0)
! Momentum score 2.9/10 — below 4.5 minimum

Earnings

B
M
M
M
1/4 beats
Next Earnings2026-08-06 (79d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is IOVA stock a buy right now?

Sell if holding. Engine safety override at $3.46: Quality below floor (3.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10 and A.R:R 8.1:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 28%; Below-average business quality; Negative price momentum. Chart setup: RSI 54 mid-range, Bollinger mid-band. Prior stop was $3.22. Score 5.7/10, moderate confidence.

What is the IOVA stock price target?

Take-profit target: $7.66 (+121.4% upside). Prior stop was $3.22. Stop-loss: $3.22.

What are the risks of investing in IOVA?

Quality below floor (3.2 < 4.0).

Is IOVA overvalued or undervalued?

Iovance Biotherapeutics, Inc. trades at a P/E of N/A (forward -10.1). TrendMatrix value score: 8.1/10. Verdict: Sell.

What do analysts say about IOVA?

17 analysts cover IOVA with a consensus score of 3.9/5. Average price target: $9.

What does Iovance Biotherapeutics, Inc. do?Iovance Biotherapeutics is a commercial-stage biopharmaceutical company selling Amtagvi (lifileucel), the first...

Iovance Biotherapeutics is a commercial-stage biopharmaceutical company selling Amtagvi (lifileucel), the first approved TIL cell therapy for advanced melanoma, and Proleukin (aldesleukin). Revenue from Amtagvi infusions is recognized upon infusion; Proleukin sells through distributors for use in Amtagvi regimens and other oncology applications.

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