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CRISPR Therapeutics AG (CRSP) Stock Analysis

SellVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $47.73: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 27%; Below-average business quality; Negative price momentum.

CRISPR Therapeutics is a biopharmaceutical company developing CRISPR/Cas9 gene-editing therapies across hemoglobinopathies, in vivo liver editing, CAR T cell therapy, and regenerative medicine. CASGEVY (co-developed and co-commercialized with Vertex Pharmaceuticals) is the... Read more

$47.73+56.6% A.UpsideScore 5.7/10#37 of 157 Biotechnology
QualityF-score4 / 9FCF yield-5.57%
Stop $45.51Target $74.54(analyst − 10%)A.R:R 5.2:1
Analyst target$82.82+73.5%22 analysts
$74.54our TP
$47.73price
$82.82mean
$291

Sell if holding. Engine safety override at $47.73: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 27%; Below-average business quality; Negative price momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Score 5.7/10, moderate confidence.

Passes 7/9 gates (favorable risk/reward ratio, clean insider activity, no SEC red flags, news boost analyst 0.40, earnings proximity 83d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and death cross (50MA < 200MA). Suitability: aggressive.

Recent Developments — CRISPR Therapeutics AG

Generated 2026-05-20T20:21:21Z.

Thesis

Rewards
Recent Analyst detected in news
Risks
Quality below floor (1.8 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-12.1
Mkt Cap$4.7B
EV/EBITDA-5.7
Profit Mgn0.0%
ROE-31.2%
Rev Growth68.6%
Beta1.74
DividendNone
Rating analysts35

Quality Signals

Piotroski F4/9

Options Flow

P/C1.11bearish
IV63%elevated

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results. Full disclaimer

Rating Breakdown

2 floor-breakers·2 ceiling hits

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
4.4
Current Ratio
5.0
Moat
5.0
Cash-burning: FCF -6359% of revenueNo competitive moatQuality concerns

Price action weak — below key moving averages, no momentum carry. Needs a base before trend-continuation setups apply.static

Macd
0.0
Obv
1.0
Ma Position
1.5
Volume
2.9
Rsi
4.5
Volume distribution (falling OBV)Below 200-MA, MA slope flat
GatesMomentum 2.0<4.5Death cross (50MA < 200MA)A.R:R 5.2 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS BOOST ANALYST 0.40EARNINGS PROXIMITY 83d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Aggressive
RSI
43 · Neutral
20D MA 50D MA 200D MADEATH CROSSSupport $46.92Resistance $57.99

Price Targets

$46
$75
A.Upside+56.2%
A.R:R5.2:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.8 < 4.0)
! Momentum score 2.0/10 — below 4.5 minimum
! Death cross — 50-day MA below 200-day MA

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-10 (83d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is CRSP stock a buy right now?

Sell if holding. Engine safety override at $47.73: Quality below floor (1.8 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.7/10 and A.R:R 5.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 27%; Below-average business quality; Negative price momentum. Chart setup: No recognized chart pattern (not a breakout, bounce, continuation, recovery, falling knife, or range) — technicals mixed. Prior stop was $45.51. Score 5.7/10, moderate confidence.

What is the CRSP stock price target?

Take-profit target: $74.54 (+56.6% upside). Prior stop was $45.51. Stop-loss: $45.51.

What are the risks of investing in CRSP?

Quality below floor (1.8 < 4.0).

Is CRSP overvalued or undervalued?

CRISPR Therapeutics AG trades at a P/E of N/A (forward -12.1). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about CRSP?

35 analysts cover CRSP with a consensus score of 3.9/5. Average price target: $83.

What does CRISPR Therapeutics AG do?CRISPR Therapeutics is a biopharmaceutical company developing CRISPR/Cas9 gene-editing therapies across...

CRISPR Therapeutics is a biopharmaceutical company developing CRISPR/Cas9 gene-editing therapies across hemoglobinopathies, in vivo liver editing, CAR T cell therapy, and regenerative medicine. CASGEVY (co-developed and co-commercialized with Vertex Pharmaceuticals) is the world's first approved CRISPR-based therapy, approved for sickle cell disease and transfusion-dependent beta thalassemia.

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