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ANROAlto Neuroscience, Inc.Sell4.8·$24.78-0.64%
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Alto Neuroscience, Inc. (ANRO) Stock Analysis

Breakout setup · Inst Constrain edge

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $24.78: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.8/10 and A.R:R 1.6:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality.

Alto Neuroscience, Inc. operates as a clinical-stage biopharmaceutical company in the United States. The company's product pipeline includes ALTO-100, which is in Phase 2b clinical trial for the treatment of patients with bipolar depression (BPD). It also develops ALTO-300, a... Read more

$24.78+23.3% A.UpsideScore 4.8/10#173 of 258 Biotechnology
QualityF-score2 / 9FCF yield-4.64%
Stop $23.05Target $30.56(analyst − 13%)A.R:R 1.6:1
Analyst target$35.13+41.8%11 analysts
$30.56our TP
$24.78price
$35.13mean
$50

Sell if holding. Engine safety override at $24.78: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.8/10 and A.R:R 1.6:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 65, MACD bullish. Score 4.8/10, moderate confidence.

Passes 8/9 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity 39d clear, semi cycle peak clear, materials cycle peak clear). Suitability: speculative.

TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Wed, Aug 12, 202639d to earnings· next earnings call

Thesis

Rewards
No bull case signals
Risks
Quality below floor (1.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-7.2
Mkt Cap$870M
EV/EBITDA-8.2
Profit Mgn0.0%
ROE-38.9%
Rev Growth
Beta1.07
DividendNone
Rating analysts18

Quality Signals

Piotroski F2/9

Options Flow

P/C1.25bearish
IV129%elevated

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Methodology · Editorial policy & full disclaimer

Rating Breakdown

3 floor-breakers

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
2.2
Moat
3.2
Current Ratio
5.0
Cash-burning (FCF negative)No competitive moatWeak Piotroski F-Score: 2/9Quality concerns

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Surprise Avg
0.0
Earnings History
3.3
Erm
5.0
Earnings Timing
5.0
Earnings concerns: 2B/2M

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
4.4
Value Rank
5.0
Growth Rank
5.0
GatesMomentum 5.3<5.5 (soft — BUY_NOW allowed but watch)Momentum 5.3>=4.5A.R:R 1.6 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 39d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARBreakoutSuitability: Speculative
RSI
65 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $17.90Resistance $28.30

Price Targets

$23
$31
A.Upside+23.3%
A.R:R1.6:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.2 < 4.0)

Earnings

B
B
M
M
2/4 beats
Next Earnings2026-08-12 (39d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is ANRO stock a buy right now?

Sell if holding. Engine safety override at $24.78: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.8/10 and A.R:R 1.6:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality. Chart setup: Golden cross, above all MAs, RSI 65, MACD bullish. Prior stop was $23.05. Score 4.8/10, moderate confidence.

What is the ANRO stock price target?

Take-profit target: $30.56 (+23.3% upside). Prior stop was $23.05. Stop-loss: $23.05.

What are the risks of investing in ANRO?

Quality below floor (1.2 < 4.0).

Is ANRO overvalued or undervalued?

Alto Neuroscience, Inc. trades at a P/E of N/A (forward -7.2). TrendMatrix value score: 7.5/10. Verdict: Sell.

What do analysts say about ANRO?

18 analysts cover ANRO with a consensus score of 4.4/5. Average price target: $35.

What does Alto Neuroscience, Inc. do?Alto Neuroscience, Inc. operates as a clinical-stage biopharmaceutical company in the United States. The company's...

Alto Neuroscience, Inc. operates as a clinical-stage biopharmaceutical company in the United States. The company's product pipeline includes ALTO-100, which is in Phase 2b clinical trial for the treatment of patients with bipolar depression (BPD). It also develops ALTO-300, a small molecule melatonergic agonist and serotonergic antagonist with antidepressant properties, which is in Phase 2b clinical trial to treat patients with major depressive disorder (MDD); ALTO-101, a novel small molecule phosphodiesterase 4 inhibitor that is in Phase 2 proof-of-concept (POC) trial for the treatment of cognitive impairment associated with schizophrenia; ALTO-203, a novel small-molecule histamine H3 receptor inverse agonist, which is in Phase 2 POC trial to treat patients with MDD and higher levels of anhedonia; ALTO-202, an investigational orally bioavailable antagonist of the GluN2B subunit of the NMDA receptor that is in Phase 1 clinical trial for the treatment of MDD; and ALTO-208, a fixed-dose combination of pramipexole and aprepitant, an antiemetic, neurokinin-1 (NK-1) receptor antagonist for patients with Parkinson's disease for patients with Parkinson's disease. The company was incorporated in 2019 and is headquartered in Mountain View, California.

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