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PVLAPalvella Therapeutics, Inc.Sell5.1·$114.25+5.00%
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Palvella Therapeutics, Inc. (PVLA) Stock Analysis

Range Bound setup

SellModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $114.25: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.1/10 and A.R:R 6.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Below-average business quality.

Palvella Therapeutics is a clinical-stage biopharma using its QTORIN platform to develop topical therapies for rare skin diseases and vascular malformations. Lead asset QTORIN rapamycin met its primary endpoint in the Phase 3 SELVA trial for microcystic lymphatic malformations... Read more

$114.25+80.0% A.UpsideScore 5.1/10#104 of 157 Biotechnology
QualityF-score2 / 9FCF yield-1.38%
Stop $106.76Target $206.64(analyst − 10%)A.R:R 6.2:1
Analyst target$229.60+101.0%15 analysts
$206.64our TP
$114.25price
$229.60mean
$270

Sell if holding. Engine safety override at $114.25: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.1/10 and A.R:R 6.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Below-average business quality. Chart setup: RSI 47 mid-range, Bollinger mid-band. Score 5.1/10, moderate confidence.

Passes 7/8 gates (positive momentum, favorable risk/reward ratio, clean insider activity, news events none recent, earnings proximity 59d clear, semi cycle peak clear, materials cycle peak clear). Suitability: aggressive.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-06-15
TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Thu, Aug 13, 202659d to earnings· next earnings call

Thesis

Rewards
No bull case signals
Risks
Concentration risk — Pipeline: QTORIN rapamycin
Quality below floor (1.2 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-16.0
Mkt Cap$1.6B
EV/EBITDA
Profit Mgn0.0%
ROE-34.2%
Rev Growth
Beta
DividendNone
Rating analysts23

Quality Signals

Piotroski F2/9

Options Flow

P/C0.31bullish
IV102%elevated
Max Pain$195+70.7% vs spot

Concentration Risks(10-K Item 1A)

  • HIGHpipelineQTORIN rapamycin
    10-K Item 1A: 'Our future success is substantially dependent on the successful clinical development, regulatory approval and commercialization of QTORIN rapamycin, which is in later stages of development than our other product candidates.'

Material Events(8-K, last 90d)

  • 2026-04-13Item 5.02LOW
    Board increased from 6 to 7 members; John Doux, M.D. appointed as Class III director effective April 13, 2026 (term expiring at 2026 Annual Meeting). Routine board expansion; no officer departure.
    SEC filing →

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Performance. Past performance is not indicative of future results. Performance figures reflect the published model only and do not reflect any individual subscriber's actual results.

Methodology · Editorial policy & full disclaimer

Rating Breakdown

5 floor-breakers·1 ceiling hit

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Roe
0.0
Roa
0.0
Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Fcf Quality
0.0
Piotroski F
2.2
Moat
3.2
Current Ratio
5.0
Cash-burning (FCF negative)No competitive moatWeak Piotroski F-Score: 2/9Quality concerns

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Earnings History
0.0
Surprise Avg
0.0
Erm
5.0
Earnings Timing
5.0
Earnings concerns: 0B/4M

Volatile — 6.1% daily ATR makes tight stops impractical. Position-size conservatively.static

Days To Cover
0.0
Volatility
0.0
Implied Vol
0.0
Debt Equity
0.0
Short Interest
1.8
Max Pain Risk
7.0
Put Call
10.0
High short interest justified: 17%High IV: 102%Concentration risks: 1 HIGH (10-K Item 1A — sized via position_sizing, validated via buy_confidence)

Ranks in the bottom of its industry peers on the composite signal. Better names in the same sector exist.static

Quality Rank
4.4
Value Rank
5.0
Growth Rank
5.0

Technicals below the gate floor. Component breakdown shows what dragged the score down.static

Support Resistance
2.6
Bollinger
3.3
Gap
4.0
52w Position
5.2
GatesExecutive change: officer departure/appointmentMomentum 6.5>=5.5A.R:R 6.2 ≥ 1.5Insider activity: OKNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 59d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARRange BoundSuitability: Aggressive
RSI
47 · Neutral
20D MA 50D MA 200D MAGOLDEN CROSSSupport $100.00Resistance $120.00

Price Targets

$107
$207
A.Upside+80.9%
A.R:R6.2:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.2 < 4.0)

Earnings

M
M
M
M
0/4 beats
Next Earnings2026-08-13 (59d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is PVLA stock a buy right now?

Sell if holding. Engine safety override at $114.25: Quality below floor (1.2 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.1/10 and A.R:R 6.2:1 is above the 1.5:1 BUY gate. Specifically: High short interest: 17%; Below-average business quality. Chart setup: RSI 47 mid-range, Bollinger mid-band. Prior stop was $106.76. Score 5.1/10, moderate confidence.

What is the PVLA stock price target?

Take-profit target: $206.64 (+80.0% upside). Prior stop was $106.76. Stop-loss: $106.76.

What are the risks of investing in PVLA?

Concentration risk — Pipeline: QTORIN rapamycin; Quality below floor (1.2 < 4.0).

Is PVLA overvalued or undervalued?

Palvella Therapeutics, Inc. trades at a P/E of N/A (forward -16.0). TrendMatrix value score: 9.0/10. Verdict: Sell.

What do analysts say about PVLA?

23 analysts cover PVLA with a consensus score of 4.3/5. Average price target: $230.

What does Palvella Therapeutics, Inc. do?Palvella Therapeutics is a clinical-stage biopharma using its QTORIN platform to develop topical therapies for rare...

Palvella Therapeutics is a clinical-stage biopharma using its QTORIN platform to develop topical therapies for rare skin diseases and vascular malformations. Lead asset QTORIN rapamycin met its primary endpoint in the Phase 3 SELVA trial for microcystic lymphatic malformations (February 2026); NDA submission is planned for H2 2026. QTORIN pitavastatin targets DSAP in IND-enabling development.

Related stocks: AUPH (Aurinia Pharmaceuticals Inc) · HALO (Halozyme Therapeutics, Inc.) · AAPG (Ascentage Pharma Group Internat) · INVA (Innoviva, Inc.) · ADMA (ADMA Biologics Inc)
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