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SPTXSeaport Therapeutics, Inc.Sell5.1·$20.51-4.38%
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Seaport Therapeutics, Inc. (SPTX) Stock Analysis

Inst Constrain edge

SellVALUE-TRAP 1/5Moderate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $20.51: Quality below floor (1.9 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.1/10 and A.R:R 3.0:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality.

Seaport Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company advancing the development of novel neuropsychiatric medicines. The company develops therapeutic candidates for conditions such as depression and anxiety disorders using its proprietary Glyph... Read more

$20.51+44.6% A.UpsideScore 5.1/10#124 of 258 Biotechnology
QualityF-score2 / 9FCF yield
Stop $19.13Target $29.75(analyst − 15%)A.R:R 3.0:1
Analyst target$35.00+70.6%4 analysts
$29.75our TP
$20.51price
$35.00mean
$40

Sell if holding. Engine safety override at $20.51: Quality below floor (1.9 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.1/10 and A.R:R 3.0:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality. Chart setup: No clear chart pattern; technical signals are mixed. Score 5.1/10, moderate confidence.

Passes 8/9 gates (positive momentum, favorable risk/reward ratio, clean insider activity, no SEC red flags, news events none recent, earnings proximity no date, semi cycle peak clear, materials cycle peak clear). Suitability: speculative.

Thesis

Rewards
No bull case signals
Risks
Quality below floor (1.9 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-8.4
Mkt Cap$1.1B
EV/EBITDA-13.0
Profit Mgn0.0%
ROE
Rev Growth
Beta
DividendNone
Rating analysts4

Quality Signals

Piotroski F2/9

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Methodology · Editorial policy & full disclaimer

Rating Breakdown

3 floor-breakers·1 ceiling hit

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Earnings History
0.0
Surprise Avg
0.0

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Gross Margin
0.0
Operating Margin
0.0
Net Margin
0.0
Piotroski F
2.2
Moat
4.0
Current Ratio
5.0
No competitive moatWeak Piotroski F-Score: 2/9Quality concerns

Volatile — 7.0% daily ATR makes tight stops impractical. Position-size conservatively.static

Days To Cover
0.0
Volatility
0.0
Debt Equity
2.5
Short Interest
8.1
GatesMomentum 4.7<5.5 (soft — BUY_NOW allowed but watch)Momentum 4.7>=4.5A.R:R 3.0 ≥ 1.5Insider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY NO DATESEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Speculative
RSI
64 · Neutral
20D MA 50D MA 200D MASupport $16.00Resistance $22.98

Price Targets

$19
$30
A.Upside+45.1%
A.R:R3.0:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Quality below floor (1.9 < 4.0)

Earnings

M
M
M
M
0/4 beats

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is SPTX stock a buy right now?

Sell if holding. Engine safety override at $20.51: Quality below floor (1.9 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 5.1/10 and A.R:R 3.0:1 is above the 1.5:1 BUY gate. Specifically: Below-average business quality. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $19.13. Score 5.1/10, moderate confidence.

What is the SPTX stock price target?

Take-profit target: $29.75 (+44.6% upside). Prior stop was $19.13. Stop-loss: $19.13.

What are the risks of investing in SPTX?

Quality below floor (1.9 < 4.0).

Is SPTX overvalued or undervalued?

Seaport Therapeutics, Inc. trades at a P/E of N/A (forward -8.4). TrendMatrix value score: 9.0/10. Verdict: Sell.

0
What does Seaport Therapeutics, Inc. do?Seaport Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company advancing the development of novel...

Seaport Therapeutics, Inc. operates as a clinical-stage biopharmaceutical company advancing the development of novel neuropsychiatric medicines. The company develops therapeutic candidates for conditions such as depression and anxiety disorders using its proprietary Glyph technology platform. The Glyph platform is designed to enable oral bioavailability, bypass first-pass metabolism, and reduce liver enzyme elevations or hepatotoxicity and other side effects. All therapeutic candidates in development are based on this platform, with research and development activities focused on neuropsychiatric medicines. The company serves clinicians and key opinion leaders in the healthcare and neuropsychiatric medicine sectors. The company was founded in 2024 and is based in Boston, Massachusetts.

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