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PBLSParabilis Medicines, Inc.Sell4.4·$40.11+1.62%
SellModerate Confidence
Investment thesis

Parabilis Medicines cannot currently be evaluated on price-based measures due to a missing price feed, and the available fundamentals point to margin compression, insider selling, and below-average quality that argue for caution once trading data is restored.

Thesis pillars

  • Value Trap Signals Margin And Insider SellingDeteriorating
  • Data Outage Blocks Trade SetupDeteriorating
  • Quality Concerns FlaggedStable
  • +2 more pillars — see the Why tab for full reasoning

Full reasoning →

Open full analysis

Parabilis Medicines, Inc. (PBLS) Stock Analysis

SellVALUE-TRAP 1/5QualityModerate Confidence

Healthcare · Biotechnology

Sell if holding. Engine safety override at $40.11: Quality below floor (3.0 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10. Specifically: Elevated put/call ratio: 2.40; Below-average business quality; Rich valuation.

Parabilis Medicines, Inc. operates as a clinical-stage biopharmaceutical company focused on developing helical peptide therapeutics for disease treatment. The company develops stabilized helical peptide therapeutics through its Helicon discovery platform, targeting proteins that... Read more

$40.11-11.5% A.UpsideScore 4.4/10#228 of 259 Biotechnology
QualityF-score4 / 9FCF yield
Stop $37.30Target $46.13(default +15%)A.R:R -0.8:1
Analyst target$41.75+4.1%4 analysts
$46.13our TP
$40.11price
$41.75mean
$46

Sell if holding. Engine safety override at $40.11: Quality below floor (3.0 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10. Specifically: Elevated put/call ratio: 2.40; Below-average business quality; Rich valuation. Chart setup: No clear chart pattern; technical signals are mixed. Score 4.4/10, moderate confidence.

Passes 6/8 gates (clean insider activity, no SEC red flags, news events none recent, earnings proximity 70d clear, semi cycle peak clear, materials cycle peak clear). Fails on weak momentum and favorable risk/reward ratio. Suitability: speculative.

news + 30-day 8-K events · 5-min refresh

Recent developments

updated 2026-09-03
TrendMatrix Research · upcoming catalyst calendar

Upcoming dated catalysts

Thu, Nov 12, 202670d to earnings· next earnings call

Thesis

Rewards
No bull case signals
Risks
Target reached (-11.5% upside)
Quality below floor (3.0 < 4.0)

Key Metrics

P/E (TTM)
P/E (Fwd)-18.1
Mkt Cap$4.9B
EV/EBITDA-22.5
Profit Mgn0.0%
ROE
Rev Growth
Beta
DividendNone
Rating analysts11

Quality Signals

Piotroski F4/9MoatNarrow

Options Flow

P/C2.40bearish
IV77%elevated

Model-generated analysis — not investment advice. Not a registered investment advisor. Past performance does not guarantee future results.

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Methodology · Editorial policy & full disclaimer

Rating Breakdown

3 floor-breakers

No near-term catalyst priced in. Thesis progression will come from fundamentals grinding, not event reaction.static

Earnings History
0.0
Surprise Avg
0.0
Erm
5.0
Earnings Timing
5.0

Priced at a premium — multiples above sector norms. Needs delivery on growth + margins to justify.static

Analyst Target
3.0
Expensive valuation
Low model confidence on this dimension (33%).

Quality below the gate floor. Component breakdown shows what dragged the score down.static

Gross Margin
0.0
Net Margin
0.0
Piotroski F
4.4
Current Ratio
5.0
Moat
5.5
Quality concerns
GatesMomentum 4.2<4.5A.R:R -0.8=NEGATIVEInsider activity: OKNo SEC red flagsNEWS EVENTS NONE RECENTEARNINGS PROXIMITY 70d clearSEMI CYCLE PEAK CLEARMATERIALS CYCLE PEAK CLEARSuitability: Speculative
RSI
71 · Overbought
20D MA 50D MA 200D MASupport $34.13Resistance $41.49

Price Targets

$37
$46
A.Upside-11.5%
A.R:R-0.8:1

Position Sizing

ConvictionNone
Suggested %0.5%
Max %1%
RegimeSteady

Risk Alerts

! Target reached (-11.5% upside)
! Quality below floor (3.0 < 4.0)
! momentum at 4.2 (below the engine's 4.5 threshold)

Earnings

M
M
M
M
0/4 beats
Next Earnings2026-11-12 (70d)

Verdict History

reverse chrono — latest first
Loading history...
Verdicts are recorded on every nightly pipeline run. Rows capture transitions (verdict flips, score deltas ≥0.3, entry/TP/SL changes). Rows with a ▶ can be expanded to see the change reason. Aggregate cohort performance is tracked in the recommendation ledger.
Frequently Asked Questions
Is PBLS stock a buy right now?

Sell if holding. Engine safety override at $40.11: Quality below floor (3.0 < 4.0) triggers a hard block regardless of the otherwise-positive setup — overall score 4.4/10. Specifically: Elevated put/call ratio: 2.40; Below-average business quality; Rich valuation. Chart setup: No clear chart pattern; technical signals are mixed. Prior stop was $37.30. Score 4.4/10, moderate confidence.

What is the PBLS stock price target?

Take-profit target: $46.13 (-11.5% upside). Prior stop was $37.30. Stop-loss: $37.30.

What are the risks of investing in PBLS?

Target reached (-11.5% upside); Quality below floor (3.0 < 4.0).

Is PBLS overvalued or undervalued?

Parabilis Medicines, Inc. trades at a P/E of N/A (forward -18.1). TrendMatrix value score: 3.0/10. Verdict: Sell.

What do analysts say about PBLS?

11 analysts cover PBLS with a consensus score of 4.4/5. Average price target: $42.

What does Parabilis Medicines, Inc. do?Parabilis Medicines, Inc. operates as a clinical-stage biopharmaceutical company focused on developing helical peptide...

Parabilis Medicines, Inc. operates as a clinical-stage biopharmaceutical company focused on developing helical peptide therapeutics for disease treatment. The company develops stabilized helical peptide therapeutics through its Helicon discovery platform, targeting proteins that are traditionally considered undruggable. Its pipeline includes functional inhibitors of intracellular protein-protein interactions, targeted protein degraders, and targeted radiopharmaceuticals, with a lead clinical program, FOG-001, that acts as a TCF-blocking beta-catenin inhibitor for cancer treatment. The company integrates artificial intelligence and data science into drug discovery, trial design, and clinical strategy optimization. Parabilis Medicines serves clients in the healthcare and life sciences industries, including clinical research organizations and medical professionals involved in oncology and cancer treatment. The company was founded in 2015 and is based in Cambridge, Massachusetts.

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