Updated
The most significant concentration Monte Rosa Therapeutics discloses is MRT-2359, MRT-6160, and MRT-8102 lead programs, classified MEDIUM by disclosed size. Below: the full set from the latest 10-K — verbatim quotes, filing references, and a synthesis of what these exposures mean together.
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Source: Monte Rosa Therapeutics’s SEC Form 10-K filed — view the filing on SEC EDGAR ↗
Each card carries a disclosed-size chip (HIGH / MEDIUM / LOW — how large the exposure is as a share of revenue, not how dangerous it is) and a nature tag: Built-in(the company’s own model, geography, or products) or Outside party (an external customer, supplier, or distributor it relies on).
“10-K Item 1A: 'Our business is dependent on the success of our lead programs, and any other product candidates that we advance into the clinic. We cannot be certain that we will be able to obtain regulatory approval for, or successfully commercialize, any of our current or future product candidates.'”
Monte Rosa Therapeutics' concentration risk is clinical-stage and pipeline-based rather than customer- or geography-driven. The company discloses that its business is dependent on the success of its lead programs — MRT-2359, MRT-6160, and MRT-8102 — and any other product candidates it advances into the clinic, with no assurance of obtaining regulatory approval for, or successfully commercializing, any current or future candidate. This is a mixed-character exposure: it combines the structural reality of a clinical-stage biotech having only a handful of programs with the idiosyncratic risk that any single trial or regulatory outcome could determine the company's trajectory. No percentage or revenue-based concentration is disclosed, since Monte Rosa is pre-commercial; the risk is binary in nature — success or failure of specific molecules — rather than a share-of-revenue exposure that can be sized the way a commercial company's customer or geographic concentration can be. For an educated investor, this means the standard sell-side concentration framework applies less cleanly here: the relevant question is pipeline diversification and clinical readouts, not the percentage-of-revenue concentrations that dominate analysis of commercial-stage companies.
For the engine’s reasoning on GLUE’s current verdict — including which dimensions drove the score — see the per-dimension breakdown.
| Symbol | Name | HIGH | MEDIUM | LOW | Total |
|---|---|---|---|---|---|
| ACAD | ACADIA Pharmaceuticals Inc. | 2 | 0 | 0 | 2 |
| ABUS | Arbutus Biopharma Corporation | 1 | 1 | 0 | 2 |
| ABSI | Absci Corporation | 1 | 0 | 0 | 1 |
| GLUE● | Monte Rosa Therapeutics, Inc. | 0 | 1 | 0 | 1 |
| ABCL | AbCellera Biologics Inc. | 0 | 0 | 0 | 0 |
| ACHV | Achieve Life Sciences, Inc. | 0 | 0 | 0 | 0 |
Concentration counts reflect items disclosed in each peer’s most recent 10-K; disclosed-size classification uses TrendMatrix’s internal 10-K extraction taxonomy.